Vandetanib-d6 is a deuterium-labeled derivative of Vandetanib, a potent and orally active inhibitor of the VEGFR2/KDR tyrosine kinase with an IC50 value of 40 nM. This compound also exhibits inhibition against VEGFR3/FLT4 (IC50 = 110 nM) and EGFR/HER1 (IC50 = 500 nM). Vandetanib-d6 is particularly valuable in pharmacokinetic studies and metabolic research involving Vandetanib, as it enables the tracking of the compound's bioavailability and distribution in vivo.
Vandetanib-d6 is a deuterium-labeled derivative of Vandetanib, a potent and orally active inhibitor of the VEGFR2/KDR tyrosine kinase with an IC50 value of 40 nM. This compound also exhibits inhibition against VEGFR3/FLT4 (IC50 = 110 nM) and EGFR/HER1 (IC50 = 500 nM). Vandetanib-d6 is particularly valuable in pharmacokinetic studies and metabolic research involving Vandetanib, as it enables the tracking of the compound's bioavailability and distribution in vivo.
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