Fig. 1 · Structure
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Vandetanib-d6
Stable Isotope
Vandetanib-d6 is a deuterium-labeled derivative of Vandetanib, a potent and orally active inhibitor of the VEGFR2/KDR tyrosine kinase with an IC50 value of 40 nM. This compound also exhibits inhibition against VEGFR3/FLT4 (IC50 = 110 nM) and EGFR/HER1 (IC50 = 500 nM). Vandetanib-d6 is particularly valuable in pharmacokinetic studies and metabolic research involving Vandetanib, as it enables the tracking of the compound's bioavailability and distribution in vivo.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1174683-49-8 |
| Applications | Stable Isotope |
| Formula | C22H18D6BrFN4O2 |
| Molecular Weight | 481.39 |
| Synonyms | ZD6474-d6 |
| SMILES | FC1=CC(Br)=CC=C1NC2=NC=NC3=CC(OCC4CCN(CC4)C([2H])([2H])[2H])=C(C=C23)OC([2H])([2H])[2H] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.