Vardenafil dihydrochloride is a selective inhibitor of phosphodiesterase-5 (PDE5), demonstrating a potent inhibitory effect with an IC50 of 0.7 nM. It also exhibits inhibition of PDE1 and PDE6 with IC50 values of 180 nM and 11 nM, respectively, while showing minimal activity against PDE3 and PDE4. By competitively inhibiting the hydrolysis of cyclic guanosine monophosphate (cGMP), Vardenafil dihydrochloride elevates cGMP levels, making it a valuable tool for studying conditions such as erectile dysfunction, hepatitis, and diabetes.
Vardenafil dihydrochloride is a selective inhibitor of phosphodiesterase-5 (PDE5), demonstrating a potent inhibitory effect with an IC50 of 0.7 nM. It also exhibits inhibition of PDE1 and PDE6 with IC50 values of 180 nM and 11 nM, respectively, while showing minimal activity against PDE3 and PDE4. By competitively inhibiting the hydrolysis of cyclic guanosine monophosphate (cGMP), Vardenafil dihydrochloride elevates cGMP levels, making it a valuable tool for studying conditions such as erectile dysfunction, hepatitis, and diabetes.
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