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VHL Ligand 35

pVHL Ligand

VHL Ligand 35 is a selective ligand of the von Hippel-Lindau protein (pVHL) E3 ubiquitin ligase with a dissociation constant (Kd) of 0.291 μM. This compound effectively disrupts the protein-protein interaction between pVHL and hypoxia inducible factor 1α (HIF-1α), which is critical for regulating cellular responses to hypoxia. VHL Ligand 35 is valuable for research applications involving hypoxia signaling pathways and cancer biology, particularly in studies targeting the mechanisms of HIF regulation.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	1631137-31-9
Applications	pVHL Ligand
Formula	C₃₃H₄₁N₅O₅S
Molecular Weight	619.78
SMILES	C([C@@H](NC([C@H](CC1=CC=CC=C1)NC(C)=O)=O)C(C)(C)C)(=O)N2[C@H](C(NCC3=CC=C(C=C3)C4=C(C)N=CS4)=O)C[C@@H](O)C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.