VHL Ligand 35 is a selective ligand of the von Hippel-Lindau protein (pVHL) E3 ubiquitin ligase with a dissociation constant (Kd) of 0.291 μM. This compound effectively disrupts the protein-protein interaction between pVHL and hypoxia inducible factor 1α (HIF-1α), which is critical for regulating cellular responses to hypoxia. VHL Ligand 35 is valuable for research applications involving hypoxia signaling pathways and cancer biology, particularly in studies targeting the mechanisms of HIF regulation.
VHL Ligand 35 is a selective ligand of the von Hippel-Lindau protein (pVHL) E3 ubiquitin ligase with a dissociation constant (Kd) of 0.291 μM. This compound effectively disrupts the protein-protein interaction between pVHL and hypoxia inducible factor 1α (HIF-1α), which is critical for regulating cellular responses to hypoxia. VHL Ligand 35 is valuable for research applications involving hypoxia signaling pathways and cancer biology, particularly in studies targeting the mechanisms of HIF regulation.
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