Fig. 1 · Structure
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VL285 Phenol
VHL Ligand
VL285 Phenol is a phenol-based analog of VL285, serving as a ligand for the E3 ubiquitin ligase VHL. This compound enables the synthesis of HaloPROTAC3, facilitating the degradation of HaloTag7 fusion proteins with an IC50 of 0.34 μM. It is a valuable tool for research applications involving targeted protein degradation and the study of protein homeostasis in cellular systems.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 1448188-69-9 |
| Applications | VHL Ligand |
| Formula | C29H32N4O5S |
| Molecular Weight | 548.65 |
| SMILES | CC(N=CS1)=C1C2=CC(O)=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](N4CC(C=CC=C5)=C5C4=O)C(C)C)=O)=O)C=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.