Vm24-toxin (Vaejovis mexicanus peptide 24) selectively targets the Kv1.3 potassium channel, exhibiting a dissociation constant (Kd) of approximately 3 pM in lymphocytes. With over 1500-fold selectivity for Kv1.3 compared to other potassium channels, this 36-residue peptide adopts a unique cystine-stabilized α/β fold comprised of a single-turn α-helix and a three-stranded antiparallel β-sheet. Vm24-toxin effectively reduces the CD4+ effector memory T cell response following T cell receptor (TCR) stimulation, making it a valuable tool for immunological research and studies exploring T cell signaling pathways.
Vm24-toxin (Vaejovis mexicanus peptide 24) selectively targets the Kv1.3 potassium channel, exhibiting a dissociation constant (Kd) of approximately 3 pM in lymphocytes. With over 1500-fold selectivity for Kv1.3 compared to other potassium channels, this 36-residue peptide adopts a unique cystine-stabilized α/β fold comprised of a single-turn α-helix and a three-stranded antiparallel β-sheet. Vm24-toxin effectively reduces the CD4+ effector memory T cell response following T cell receptor (TCR) stimulation, making it a valuable tool for immunological research and studies exploring T cell signaling pathways.
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