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Publications citing Adooq Products
Vorapaxar (SCH 530348) Citations (5)
- Cansu Tekin,et al. PAR1 signaling on tumor cells limits tumor growth by maintaining a mesenchymal phenotype in pancreatic cancer, Oncotarget, 2018, Aug 10; 9(62): 32010-32023 30174793
- Claushuis TA,et al. Thrombin contributes to protective immunity in pneumonia-derived sepsis via fibrin polymerization and platelet-neutrophil interactions, J Thromb Haemost, 2017, Apr;15(4):744-757 28092405
- Maaike Waasdorp,et al. Plasmin reduces fibronectin deposition by mesangial cells in a protease-activated receptor-1 independent manner, Biochem Biophys Rep, 2017, Jul; 10: 152-156 29114573
- Joseph C. Mudd,et al. Inflammatory Function of CX3CR1+ CD8+ T Cells in Treated HIV Infection Is Modulated by Platelet Interactions, J Infect Dis, 2016, Dec 15; 214(12): 1808-1816 27703039
- Corey E. Tabit,et al. Elevated Angiopoietin-2 Level in Patients With Continuous-Flow Left Ventricular Assist Devices Leads to Altered Angiogenesis and Is Associated With Higher Non-Surgical Bleeding, Circulation, 2016, Jul 12; 134(2): 141-152 27354285
Chemical Information
| Catalog Num | A12832 |
|---|---|
| Actions | Antagonist |
| M. Wt | 492.58 |
| Formula | C29H33FN2O4 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 618385-01-6 |
| Synonyms | SCH530348, SCH-530348, MK-5348, MK5348, MK 5348 |
| SMILES code | CCOC(=O)N[[email protected]@H]1CC[[email protected]@H]2[[email protected]@H](C1)C[[email protected]@H]3[[email protected]]([[email protected]]2/C=C/C4=NC=C(C=C4)C5=CC(=CC=C5)F)[[email protected]](OC3=O)C |
| Chemical Name | Carbamic acid, N-[(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(1E)-2-[5-(3-fluorophenyl)-2-pyridinyl]ethenyl]dodecahydro-1-methyl-3-oxonaphtho[2,3-c]furan-6-yl]-, ethyl ester |
Description |
Vorapaxar (SCH 530348) is a potent and orally active thrombin receptor (PAR-1) antagonist with Ki of 8.1 nM. | ||||||||||
Targets |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.3 mL | 101.51 mL | 203.01mL |
| 0.5 mM | 4.06 mL | 20.3 mL | 40.6 mL |
| 1 mM | 2.03 mL | 10.15 mL | 20.3 mL |
| 5 mM | 0.41 mL | 2.03 mL | 4.06 mL |
*The above data is based on the productmolecular weight 492.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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