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Vorapaxar (SCH 530348)


PAR-1 Antagonist

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Catalog No. A12832

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Vorapaxar (SCH 530348) 5mg A12832-5

Regular Price: $130.00

Special Price: $117.00

Vorapaxar (SCH 530348) 10mg A12832-10

Regular Price: $230.00

Special Price: $207.00

Vorapaxar (SCH 530348) 25mg A12832-25

Regular Price: $460.00

Special Price: $414.00

Vorapaxar (SCH 530348) 50mg A12832-50

Regular Price: $680.00

Special Price: $612.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Vorapaxar (SCH 530348) is a potent and orally active thrombin receptor (PAR-1) antagonist with Ki of 8.1 nM.

Vorapaxar (SCH 530348)

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Publications citing Adooq Products
Vorapaxar (SCH 530348) Citations (5)
  • Cansu Tekin, .et al. PAR1 signaling on tumor cells limits tumor growth by maintaining a mesenchymal phenotype in pancreatic cancer, Oncotarget, 2018, Aug 10; 9(62): 32010-32023 PMID: 30174793
  • Claushuis TA, .et al. Thrombin contributes to protective immunity in pneumonia-derived sepsis via fibrin polymerization and platelet-neutrophil interactions, J Thromb Haemost, 2017, Apr;15(4):744-757 PMID: 28092405
  • Maaike Waasdorp, .et al. Plasmin reduces fibronectin deposition by mesangial cells in a protease-activated receptor-1 independent manner, Biochem Biophys Rep, 2017, Jul; 10: 152-156 PMID: 29114573
  • Joseph C. Mudd, .et al. Inflammatory Function of CX3CR1+ CD8+ T Cells in Treated HIV Infection Is Modulated by Platelet Interactions, J Infect Dis, 2016, Dec 15; 214(12): 1808-1816 PMID: 27703039
  • Corey E. Tabit, .et al. Elevated Angiopoietin-2 Level in Patients With Continuous-Flow Left Ventricular Assist Devices Leads to Altered Angiogenesis and Is Associated With Higher Non-Surgical Bleeding, Circulation, 2016, Jul 12; 134(2): 141-152 PMID: 27354285

Chemical Information

Catalog Num A12832
Actions Antagonist
M. Wt 492.58
Formula C29H33FN2O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 618385-01-6
Synonyms SCH530348, SCH-530348, MK-5348, MK5348, MK 5348
SMILES CCOC(=O)N[[email protected]@H]1CC[[email protected]@H]2[[email protected]@H](C1)C[[email protected]@H]3[[email protected]]([[email protected]]2/C=C/C4=NC=C(C=C4)C5=CC(=CC=C5)F)[[email protected]](OC3=O)C

Biological Activity

Vorapaxar (SCH 530348) is a potent and orally active thrombin receptor (PAR-1) antagonist with Ki of 8.1 nM.
8.1 nM(Ki)

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.3 mL 101.51 mL 203.01mL
0.5 mM 4.06 mL 20.3 mL 40.6 mL
1 mM 2.03 mL 10.15 mL 20.3 mL
5 mM 0.41 mL 2.03 mL 4.06 mL

*The above data is based on the productmolecular weight 492.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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