Vortioxetine (Lu AA21004) hydrobromide

Catalog No.: A12602

5-HT Receptor modulator

Vortioxetine (Lu AA21004) hydrobromide

Vortioxetine (Lu AA21004) hydrobromide Chemical Structure

CAS NO. 960203-27-4

Lu-AA21004 is an oral multimodal serotonergic agent, inhibits 5-HT(1A), 5-HT(1B), 5-HT(3A), 5-HT(7) and SERT with IC50 of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.

Availability: In stock

Package Price Qty
5 mg
$70.00
10 mg
$110.00
25 mg
$280.00
50 mg
$150.00
10mM * 1mL in DMSO
$77.00
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Biological Activity

Lu-AA21004 is an oral multimodal serotonergic agent, inhibits 5-HT(1A), 5-HT(1B), 5-HT(3A), 5-HT(7) and SERT with IC50 of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.
Targets
SERT 5-HT3A 5-HT1A 5-HT7 5-HT1B
1.6 nM(Ki)3.7 nM(Ki)15 nM(Ki)19 nM(Ki)33 nM(Ki)
In vitro (25°C) DMSO 68 mg/mL (179.24 mM)
Water Insoluble
Ethanol 15 mg/mL (39.54 mM)
In vivo 2% DMSO+40% PEG 300+2% Tween 80+ddH2O 6 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.36 mL 131.8 mL 263.6 mL
0.5 mM 5.27 mL 26.36 mL 52.72 mL
1 mM 2.64 mL 13.18 mL 26.36 mL
5 mM 0.53 mL 2.64 mL 5.27 mL

*The above data is based on the productmolecular weight 379.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12602
Actions Modulator
CAS No. 960203-27-4
Formula C18H22N2S.HBr
M. Wt 379.36
Purity >98%
Synonyms Lu AA21004, LuAA21004, Lu-AA21004
SMILES CC1=CC(=C(C=C1)SC2=CC=CC=C2N3CCNCC3)C.Br
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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