VU 0357121

Catalog No.: A11754

mGluR5 PAM

VU 0357121

VU 0357121 Chemical Structure

CAS NO. 433967-28-3

VU 0357121 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 5 (mGlu5) with EC50 = 33 nM, 92% Glumax.

Availability: In stock

Package Price Qty
10 mg
$90.00
25 mg
$200.00
50 mg
$380.00
100 mg
$700.00
10mM * 1mL in DMSO
$86.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

VU 0357121 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 5 (mGlu5) with EC50 = 33 nM, 92% Glumax.
Targets
mGluR5
30 nM(EC50)
In vitro DMSO 61 mg/mL (199.79 mM)
Water <1 mg/mL (<1 mM)
Ethanol 21 mg/mL (68.78 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.75 mL 163.77 mL 327.55 mL
0.5 mM 6.55 mL 32.75 mL 65.51 mL
1 mM 3.28 mL 16.38 mL 32.75 mL
5 mM 0.66 mL 3.28 mL 6.55 mL

*The above data is based on the productmolecular weight 305.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11754
Actions N/A
M. Wt 305.3
Formula C17H17F2NO2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 433967-28-3
Synonyms VU0357121,VU-0357121
SMILES CCCCOC1=CC=C(C=C1)C(=O)NC2=C(C=C(C=C2)F)F

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