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VU 0357121

mGluR5 PAM

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Catalog No. A11754

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
VU 0357121 10mg A11754-10
VU 0357121 25mg A11754-25
VU 0357121 50mg A11754-50
VU 0357121 100mg A11754-100
VU 0357121 10mM * 1mL in DMSO A11754-10mM-D

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

VU 0357121 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 5 (mGlu5) with EC50 = 33 nM, 92% Glumax.

VU 0357121

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Chemical Information

Catalog Num A11754
Actions N/A
M. Wt 305.3
Formula C17H17F2NO2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 433967-28-3
Synonyms VU0357121,VU-0357121

Biological Activity

VU 0357121 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 5 (mGlu5) with EC50 = 33 nM, 92% Glumax.
30 nM(EC50)


Solubility (25°C)* In vitro DMSO 61 mg/mL (199.79 mM)
Water <1 mg/mL (<1 mM)
Ethanol 21 mg/mL (68.78 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.75 mL 163.77 mL 327.55mL
0.5 mM 6.55 mL 32.75 mL 65.51 mL
1 mM 3.28 mL 16.38 mL 32.75 mL
5 mM 0.66 mL 3.28 mL 6.55 mL

*The above data is based on the productmolecular weight 305.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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