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VU0542270

Catalog No.: A68014
Kir6.1/SUR2B KATP channel inhibitor
VU0542270 is a selective inhibitor of the vascular Kir6.1/SUR2B KATP channel, demonstrating an IC50 value of 100 nM. It exhibits minimal activity against other members of the Kir channel family, with an IC50 greater than 30 μM for nine variants. This compound is valuable for investigating the role of KATP channels in cardiovascular disease and exploring potential therapeutic strategies.
VU0542270 1396814-79-1 Kir6.1/SUR2B KATP channel inhibitor
Grouped product items
Size Price Stock Qty
5mg
$70.00
In stock
10mg
$135.00
In stock
25mg
$330.00
In stock
50mg
$590.00
In stock
100mg
$1,035.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionVU0542270 is a selective inhibitor of the vascular Kir6.1/SUR2B KATP channel, demonstrating an IC50 value of 100 nM. It exhibits minimal activity against other members of the Kir channel family, with an IC50 greater than 30 μM for nine variants. This compound is valuable for investigating the role of KATP channels in cardiovascular disease and exploring potential therapeutic strategies.
Product Information
Catalog NumA68014
FormulaC14H13N3OS3
Molecular Weight335.47
CAS Number1396814-79-1
SMILESCC1=C(CNC(NC2=CC=CS2)=O)SC(C3=CC=CS3)=N1
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Membrane Transporters-Ion Channels > Potassium Channels