VX-809 (Lumacaftor)

Catalog No.: A10986

CFTR modulator

VX-809 (Lumacaftor)

VX-809 (Lumacaftor) Chemical Structure

CAS NO. 936727-05-8

VX-809 is the second investigational oral candidate compound for the treatment of cystic fibrosis (CF).

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Package Price Qty
5 mg
10 mg
50 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Okiyoneda T, .et al. Chaperone-Independent Peripheral Quality Control of CFTR by RFFL E3 Ligase, Dev Cell, 2018, Mar 26;44(6):694-708.e7 PMID: 29503157
  • Junko Kido, .et al. Cystic Fibrosis Transmembrane Conductance Regulator Reduces Microtubule-Dependent Campylobacter jejuni Invasion, Infect Immun, 2017, Oct; 85(10): e00311-17 PMID: 28784926

Biological Activity

VX-809 is the second investigational oral candidate compound for the treatment of cystic fibrosis (CF).
F508del-CFTR (Fisher rat thyroid cells)
0.1 μM(EC50)
In vitro (25°C) DMSO 90 mg/mL (198.93 mM)
Water <1 mg/mL (<1 mM)
Ethanol 6 mg/mL (13.26 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.1 mL 110.52 mL 221.04 mL
0.5 mM 4.42 mL 22.1 mL 44.21 mL
1 mM 2.21 mL 11.05 mL 22.1 mL
5 mM 0.44 mL 2.21 mL 4.42 mL

*The above data is based on the productmolecular weight 452.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10986
Actions Modulator
M. Wt 452.4
Formula C24H18F2N2O5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 936727-05-8
Synonyms VX809
SMILES CC1=C(N=C(C=C1)NC(=O)C2(CC2)C3=CC4=C(C=C3)OC(O4)(F)F)C5=CC(=CC=C5)C(=O)O

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