VX-809 (Lumacaftor)

VX-809 is the second investigational oral candidate compound for the treatment of cystic fibrosis (CF).
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Product Name Price Stock Qty
VX-809 5mg
In stock
VX-809 10mg
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VX-809 50mg
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VX-809 10mM * 1mL in DMSO
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's VX-809 (Lumacaftor) has been cited by 5 publications
  • Daichi Hinata, .et al. , Int J Mol Sci, 2023, Jan 24;24(3):2305 PMID: 36768629
  • Kusumika Saha, .et al. , Cell Mol Life Sci, 2022, Sep 27;79(10):530 PMID: 36167862
  • Heledd H Jarosz-Griffiths, .et al. , Elife, 2020, Mar 2;9:e54556 PMID: 32118580
  • Okiyoneda T, .et al. , Dev Cell, 2018, Mar 26;44(6):694-708.e7 PMID: 29503157
  • Junko Kido, .et al. , Infect Immun, 2017, Oct; 85(10): e00311-17 PMID: 28784926
  • Biological Activity
    Discription VX-809 is the second investigational oral candidate compound for the treatment of cystic fibrosis (CF).
    Target Value
    Product Information
    Catalog Num A10986
    Formula C24H18F2N2O5
    Molecular Weight 452.4
    CAS Number 936727-05-8
    SMILES CC1=C(N=C(C=C1)NC(=O)C2(CC2)C3=CC4=C(C=C3)OC(O4)(F)F)C5=CC(=CC=C5)C(=O)O
    Synonyms VX809

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    In vitro (25°C) DMSO 88 mg/mL (194.51 mM)
    Water Insoluble
    Ethanol 6 mg/mL (13.26 mM)
    In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 22.1 mL 110.52 mL 221.04 mL
    0.5 mM 4.42 mL 22.1 mL 44.21 mL
    1 mM 2.21 mL 11.05 mL 22.1 mL
    5 mM 0.44 mL 2.21 mL 4.42 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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      Molecular Weight

    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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