VX-809 (Lumacaftor)
VX-809 is the second investigational oral candidate compound for the treatment of cystic fibrosis (CF).
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Adooq Products cited in reputable paper
Adooq's VX-809 (Lumacaftor) has been cited by 6 publications
- Danny D Dinh, .et al. , EBioMedicine, 2024, Apr:102:105058 PMID: 38490104
- Daichi Hinata, .et al. , Int J Mol Sci, 2023, Jan 24;24(3):2305 PMID: 36768629
- Kusumika Saha, .et al. , Cell Mol Life Sci, 2022, Sep 27;79(10):530 PMID: 36167862
- Heledd H Jarosz-Griffiths, .et al. , Elife, 2020, Mar 2;9:e54556 PMID: 32118580
- Okiyoneda T, .et al. , Dev Cell, 2018, Mar 26;44(6):694-708.e7 PMID: 29503157
- Junko Kido, .et al. , Infect Immun, 2017, Oct; 85(10): e00311-17 PMID: 28784926
Biological Activity
| Description | VX-809 is the second investigational oral candidate compound for the treatment of cystic fibrosis (CF). | ||
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Product Information
| Catalog Num | A10986 |
|---|---|
| Formula | C24H18F2N2O5 |
| Molecular Weight | 452.4 |
| CAS Number | 936727-05-8 |
| SMILES | CC1=C(N=C(C=C1)NC(=O)C2(CC2)C3=CC4=C(C=C3)OC(O4)(F)F)C5=CC(=CC=C5)C(=O)O |
| Synonyms | VX809 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Solubility
| In vitro (25°C) | DMSO | 88 mg/mL (194.51 mM) | |
| Water | Insoluble | ||
| Ethanol | 6 mg/mL (13.26 mM) | ||
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL | |
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.1 mL | 110.52 mL | 221.04 mL |
| 0.5 mM | 4.42 mL | 22.1 mL | 44.21 mL |
| 1 mM | 2.21 mL | 11.05 mL | 22.1 mL |
| 5 mM | 0.44 mL | 2.21 mL | 4.42 mL |
Useful Calculator
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
Please check COA/MSDS for correct molecular weight.
Calculate the dilution required to prepare a stock solution.This equation is commonly abbreviated as: C1V1 = C2V2
