VX-809 (Lumacaftor)

Catalog No.: A10986

CFTR modulator

VX-809 (Lumacaftor) Chemical Structure

CAS NO. 936727-05-8

VX-809 is the second investigational oral candidate compound for the treatment of cystic fibrosis (CF).

Availability: In stock

Package Price Qty
5 mg
$45.00
10 mg
$65.00
50 mg
$100.00
10mM * 1mL in DMSO
$65.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

VX-809 is the second investigational oral candidate compound for the treatment of cystic fibrosis (CF).
Targets
F508del-CFTR (Fisher rat thyroid cells)
0.1 μM(EC50)
In vitro (25°C) DMSO 90 mg/mL (198.93 mM)
Water <1 mg/mL (<1 mM)
Ethanol 6 mg/mL (13.26 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.1 mL 110.52 mL 221.04 mL
0.5 mM 4.42 mL 22.1 mL 44.21 mL
1 mM 2.21 mL 11.05 mL 22.1 mL
5 mM 0.44 mL 2.21 mL 4.42 mL

*The above data is based on the productmolecular weight 452.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10986
Actions Modulator
M. Wt 452.4
Formula C24H18F2N2O5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 936727-05-8
Synonyms VX809
SMILES CC1=C(N=C(C=C1)NC(=O)C2(CC2)C3=CC4=C(C=C3)OC(O4)(F)F)C5=CC(=CC=C5)C(=O)O

Product Tags

Product Tags

Other people marked this product with these tags:

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
Keywords:buy VX-809 (Lumacaftor) | VX-809 (Lumacaftor) Supplier | purchase VX-809 (Lumacaftor) | VX-809 (Lumacaftor) cost | VX-809 (Lumacaftor) manufacturer | order VX-809 (Lumacaftor) | VX-809 (Lumacaftor) distributor | buy 936727-05-8| 936727-05-8 Supplier | purchase 936727-05-8 | 936727-05-8 cost | 936727-05-8 manufacturer | order 936727-05-8 | 936727-05-8 distributor
Rewards