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Biological Activity
WDR5-0103 is a small molecule that binds a peptide-binding pocket on WDR5 (Kd = 450 nM), inhibiting the catalytic activity of the MLL core complex in vitro (IC50 = 39 M).
| In vitro | DMSO | 68 mg/mL (177.34 mM) | |
| Water | Insoluble | ||
| Ethanol | 18 mg/mL (46.94 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.08 mL | 130.4 mL | 260.79 mL |
| 0.5 mM | 5.22 mL | 26.08 mL | 52.16 mL |
| 1 mM | 2.61 mL | 13.04 mL | 26.08 mL |
| 5 mM | 0.52 mL | 2.61 mL | 5.22 mL |
*The above data is based on the productmolecular weight 383.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15928 |
|---|---|
| Actions | Antagonist |
| CAS No. | 890190-22-4 |
| Formula | C21H25N3O4 |
| M. Wt | 383.45 |
| Purity | >98% |
| Synonyms | WDR 5-0103, WDR-5-0103 |
| SMILES | O=C(OC)C1=CC(NC(C2=CC=CC(OC)=C2)=O)=C(N3CCN(C)CC3)C=C1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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