WEE1-IN-14 is a selective WEE1 inhibitor, exhibiting an IC50 of 0.5 nM in L-RB-FEP calculations and 1.0 nM in the ADP-Glo kinase assay. By inhibiting WEE1, this compound disrupts the G2-M checkpoint in cancer cells, effectively removing cell cycle regulatory controls. The resulting early onset of mitotic failure triggers apoptosis in tumor cells, making WEE1-IN-14 a valuable reagent for research in cancer biology and therapeutic development.
WEE1-IN-14 is a selective WEE1 inhibitor, exhibiting an IC50 of 0.5 nM in L-RB-FEP calculations and 1.0 nM in the ADP-Glo kinase assay. By inhibiting WEE1, this compound disrupts the G2-M checkpoint in cancer cells, effectively removing cell cycle regulatory controls. The resulting early onset of mitotic failure triggers apoptosis in tumor cells, making WEE1-IN-14 a valuable reagent for research in cancer biology and therapeutic development.
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