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Catalog No.: A11187

mTOR Inhibitor


WYE-687 Chemical Structure

CAS NO. 1062161-90-3

WYE-687 is a novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin(mTOR).

Availability: In stock

Package Price Qty
5 mg

Regular Price: $80.00

Special Price $64.00

10 mg

Regular Price: $140.00

Special Price $112.00

50 mg

Regular Price: $380.00

Special Price $304.00

100 mg

Regular Price: $680.00

Special Price $544.00

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Biological Activity

WYE-687 is a novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin(mTOR).

Target Value
mTORIC50: 7nM
PI3KαIC50: 0.81μM
PI3KγIC50: 3.11μM
p38αIC50: 28.9μM
SrcIC50: >50μM
VEGFR2IC50: >50μM
Abl1IC50: >50μM
AuroraBIC50: >50μM
CDK1/CyclinBIC50: >50μM
CDK2/CyclinAIC50: >50μM
Chk1IC50: >50μM
ERK2IC50: >50μM
FynIC50: >50μM
GCKIC50: >50μM
HckIC50: >50μM
IKKαIC50: >50μM
LynIC50: >50μM
MetIC50: >50μM
MK2IC50: >50μM
PDGFRαIC50: >50μM
PKAIC50: >50μM
PKBαIC50: >50μM
PKCαIC50: >50μM
PKCβIC50: >50μM
ROCK1IC50: >50μM
RSK1IC50: >50μM
In vitro DMSO 0.45 mg/mL (0.85 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.92 mL 94.59 mL 189.18 mL
0.5 mM 3.78 mL 18.92 mL 37.84 mL
1 mM 1.89 mL 9.46 mL 18.92 mL
5 mM 0.38 mL 1.89 mL 3.78 mL

*The above data is based on the productmolecular weight 528.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11187
Actions Inhibitor
CAS No. 1062161-90-3
Formula C28H32N8O3
M. Wt 528.61
Purity >98%
Synonyms WYE687

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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