WZ3146

Catalog No.: A10990

EGFR Inhibitor

WZ3146

WZ3146 Chemical Structure

CAS NO. 1214265-56-1

WZ3146 is an inhibitor of EGFR receptor kinase mutants carrying a mutation in an active site gatekeeper residue (T790M) and is much less potent against wild-type EGFR kinase.

Availability: In stock

Package Price Qty
5 mg
$70.00
10 mg
$120.00
50 mg
$350.00
100 mg
$600.00
10mM * 1mL in DMSO
$124.00
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Biological Activity

WZ3146 is an inhibitor of EGFR receptor kinase mutants carrying a mutation in an active site gatekeeper residue (T790M) and is much less potent against wild-type EGFR kinase.
Targets
EGFR (L858R) EGFR (E746_A750) EGFR (L858R/T790M) EGFR (E746_A750/T790M)
2 nM2 nM5 nM14 nM
In vitro DMSO 83 mg/mL (178.51 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.51 mL 107.53 mL 215.05 mL
0.5 mM 4.3 mL 21.51 mL 43.01 mL
1 mM 2.15 mL 10.75 mL 21.51 mL
5 mM 0.43 mL 2.15 mL 4.3 mL

*The above data is based on the productmolecular weight 465.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10990
Actions Inhibitor
CAS No. 1214265-56-1
Formula C24H25ClN6O2
M. Wt 465.0
Purity >98%
Synonyms WZ-3146
SMILES CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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