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Chemical Information
Catalog Num | A10990 |
---|---|
Actions | Inhibitor |
M. Wt | 465.0 |
Formula | C24H25ClN6O2 |
Solubility | DMSO |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 1214265-56-1 |
Synonyms | WZ-3146 |
SMILES code | CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl |
Chemical Name | N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide |
Description |
WZ3146 is an inhibitor of EGFR receptor kinase mutants carrying a mutation in an active site gatekeeper residue (T790M) and is much less potent against wild-type EGFR kinase. | ||||||||||
Targets |
|
Solubility (25°C)* | In vitro | DMSO | 93 mg/mL (200.02 mM) |
---|---|---|---|
Water | <1 mg/mL (<1 mM) | ||
Ethanol | <1 mg/mL (<1 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 21.51 mL | 107.53 mL | 215.05mL |
0.5 mM | 4.3 mL | 21.51 mL | 43.01 mL |
1 mM | 2.15 mL | 10.75 mL | 21.51 mL |
5 mM | 0.43 mL | 2.15 mL | 4.3 mL |
*The above data is based on the productmolecular weight 465.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Cat. No. | Product Name | Solubility(mg/mL) | ||
---|---|---|---|---|
Water | DMSO | Ethanol | ||
A10043 | AEE788 | <1 mg/mL | 88 mg/mL | <1 mg/mL |
A11022 | AG-1478 (Tyrphostin AG-1478) | <1 mg/mL | 25 mg/mL | 13 mg/mL |
A10047 | AG 490 | <1 mg/mL | 59 mg/mL | 6 mg/mL |
A11027 | ARRY-380 | <1 mg/mL | 114 mg/mL | <1 mg/mL |
A11158 | ARRY334543 | <1 mg/mL | 6 mg/mL | <1 mg/mL |
A11155 | AST-1306 | <1 mg/mL | 124 mg/mL | <1 mg/mL |
A10116 | AZD8931 | <1 mg/mL | 40 mg/mL | <1 mg/mL |
A11334 | BIBX 1382 | 50 mg/mL | 50 mg/mL | N/A |
A11209 | Lenalidomide (CC-5013) | <1 mg/mL | 113 mg/mL | 20 mg/mL |
A10743 | BMS 599626 (AC480) | <1 mg/mL | 55 mg/mL | <1 mg/mL |
A10211 | Canertinib (CI-1033) | <1 mg/mL | 2 mg/mL | 9 mg/mL |
A10210 | Chrysophanic acid (Chrysophanol) | <1 mg/mL | <1 mg/mL | <1 mg/mL |
A10242 | CP-724714 | <1 mg/mL | 94 mg/mL | 94 mg/mL |
A10362 | Erlotinib hydrochloride | <1 mg/mL | 3 mg/mL | <1 mg/mL |
A10422 | Gefitinib (Iressa) | <1 mg/mL | 89 mg/mL | 4 mg/mL |
A10514 | Lapatinib Ditosylate | <1 mg/mL | 185 mg/mL | <1 mg/mL |
A10612 | Mubritinib (TAK 165) | 13 mg/mL | <1 mg/mL | <1 mg/mL |
A10638 | Neratinib (HKI-272) | 2 mg/mL | <1 mg/mL | <1 mg/mL |
A10678 | OSI-420 | 83 mg/mL | 2 mg/mL | <1 mg/mL |
A10702 | PD153035 (HCl salt) | <1 mg/mL | <1 mg/mL | <1 mg/mL |
A10706 | Pelitinib (EKB-569) | <1 mg/mL | 13 mg/mL | <1 mg/mL |
A11051 | PF299804 | <1 mg/mL | 19 mg/mL | <1 mg/mL |
A11236 | TAK-285 | <1 mg/mL | 110 mg/mL | 54 mg/mL |
A10053 | Tyrphostin AG 879 | 36 mg/mLtd | <1 mg/mL | 3 mg/mL |
A10990 | WZ3146 | <1 mg/mL | 93 mg/mL | <1 mg/mL |
A10991 | WZ4002 | 13 mg/mL | <1 mg/mL | <1 mg/mL |
A10992 | WZ8040 | 96 mg/mL | <1 mg/mL | 3 mg/mL |
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