WZ3146

Catalog No.: A10990

EGFR Inhibitor

WZ3146

WZ3146 Chemical Structure

CAS NO. 1214265-56-1

WZ3146 is an inhibitor of EGFR receptor kinase mutants carrying a mutation in an active site gatekeeper residue (T790M) and is much less potent against wild-type EGFR kinase.

Availability: In stock

Package Price Qty
5 mg
$70.00
10 mg
$120.00
50 mg
$350.00
100 mg
$600.00
10mM * 1mL in DMSO
$124.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

WZ3146 is an inhibitor of EGFR receptor kinase mutants carrying a mutation in an active site gatekeeper residue (T790M) and is much less potent against wild-type EGFR kinase.
Targets
EGFR (L858R) EGFR (E746_A750) EGFR (L858R/T790M) EGFR (E746_A750/T790M)
2 nM2 nM5 nM14 nM
In vitro DMSO 93 mg/mL (200.02 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.51 mL 107.53 mL 215.05 mL
0.5 mM 4.3 mL 21.51 mL 43.01 mL
1 mM 2.15 mL 10.75 mL 21.51 mL
5 mM 0.43 mL 2.15 mL 4.3 mL

*The above data is based on the productmolecular weight 465.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10990
Actions Inhibitor
M. Wt 465.0
Formula C24H25ClN6O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1214265-56-1
Synonyms WZ-3146
SMILES CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl

Product Tags

Product Tags

Other people marked this product with these tags:

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
You may also be interested in the following product(s)
Keywords:buy WZ3146 | WZ3146 Supplier | purchase WZ3146 | WZ3146 cost | WZ3146 manufacturer | order WZ3146 | WZ3146 distributor | buy 1214265-56-1| 1214265-56-1 Supplier | purchase 1214265-56-1 | 1214265-56-1 cost | 1214265-56-1 manufacturer | order 1214265-56-1 | 1214265-56-1 distributor
Rewards