WZ3146

Name: WZ3146
Brand: Adooq Bioscience
SKU: A10990
Rating: 100 (268 reviews)

Catalog No.: A10990

EGFR Inhibitor

WZ3146 Chemical Structure

CAS NO. 1214265-56-1

WZ3146 is an inhibitor of EGFR receptor kinase mutants carrying a mutation in an active site gatekeeper residue (T790M) and is much less potent against wild-type EGFR kinase.

Availability: In stock

Package	Price	Qty
5 mg	$70.00
10 mg	$120.00
50 mg	$350.00
100 mg	$600.00
10mM * 1mL in DMSO	$124.00
Custom Size	Get quote

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Biological Activity

WZ3146 is an inhibitor of EGFR receptor kinase mutants carrying a mutation in an active site gatekeeper residue (T790M) and is much less potent against wild-type EGFR kinase.

Targets

EGFR (L858R)	EGFR (E746_A750)	EGFR (L858R/T790M)	EGFR (E746_A750/T790M)
2 nM	2 nM	5 nM	14 nM

Solubility *

In vitro	DMSO	83 mg/mL (178.51 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.51 mL	107.53 mL	215.05 mL
0.5 mM	4.3 mL	21.51 mL	43.01 mL
1 mM	2.15 mL	10.75 mL	21.51 mL
5 mM	0.43 mL	2.15 mL	4.3 mL

*The above data is based on the productmolecular weight 465.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10990
Actions	Inhibitor
CAS No.	1214265-56-1
Formula	C24H25ClN6O2
M. Wt	465.0
Solubility	DMSO
Purity	>98%
Synonyms	WZ-3146
SMILES	CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.