WZ4002

Name: WZ4002
Brand: Adooq Bioscience
SKU: A10991
Rating: 100 (268 reviews)

Catalog No.: A10991

EGFR Inhibitor

WZ4002 Chemical Structure

CAS NO. 1213269-23-8

WZ4002 is EGFR inhibitor against EGFR T790M (mutation of the gatekeeper T790 residue) which is detected in 50% of clinically resistant patients to gefitinib or erlotinib.

Availability: In stock

Package	Price	Qty
10 mg	$70.00
50 mg	$200.00
100 mg	$350.00
200 mg	$600.00
10mM * 1mL in DMSO	$94.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Biological Activity

WZ4002 is EGFR inhibitor against EGFR T790M (mutation of the gatekeeper T790 residue) which is detected in 50% of clinically resistant patients to gefitinib or erlotinib.

Targets

EGFR (L858R) (BaF3 cells)	EGFR (L858R/T790M) (BaF3 cells)
2 nM	8 nM

Solubility *

In vitro (25°C)	DMSO	12 mg/mL (24.28 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.2 mL	101.01 mL	202.02 mL
0.5 mM	4.04 mL	20.2 mL	40.4 mL
1 mM	2.02 mL	10.1 mL	20.2 mL
5 mM	0.4 mL	2.02 mL	4.04 mL

*The above data is based on the productmolecular weight 495.0. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10991
Actions	Inhibitor
CAS No.	1213269-23-8
Formula	C25H27ClN6O3
M. Wt	495.0
Purity	>98%
SMILES	CN1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl)OC
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.