WZ4002

Catalog No.: A10991

EGFR Inhibitor

WZ4002 Chemical Structure

CAS NO. 1213269-23-8

WZ4002 is EGFR inhibitor against EGFR T790M (mutation of the gatekeeper T790 residue) which is detected in 50% of clinically resistant patients to gefitinib or erlotinib.

Availability: In stock

Package Price Qty
10 mg
$70.00
50 mg
$200.00
100 mg
$350.00
200 mg
$600.00
10mM * 1mL in DMSO
$94.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

WZ4002 is EGFR inhibitor against EGFR T790M (mutation of the gatekeeper T790 residue) which is detected in 50% of clinically resistant patients to gefitinib or erlotinib.
Targets
EGFR (L858R) (BaF3 cells) EGFR (L858R/T790M) (BaF3 cells)
2 nM8 nM
In vitro (25°C) DMSO 13 mg/mL (26.3 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.2 mL 101.01 mL 202.02 mL
0.5 mM 4.04 mL 20.2 mL 40.4 mL
1 mM 2.02 mL 10.1 mL 20.2 mL
5 mM 0.4 mL 2.02 mL 4.04 mL

*The above data is based on the productmolecular weight 495.0. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10991
Actions Inhibitor
M. Wt 495.0
Formula C25H27ClN6O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1213269-23-8
Synonyms N/A
SMILES CN1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl)OC

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