Fig. 1 · Structure
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Xaliproden hydrochloride
5-HT1A Agonist
Xaliproden hydrochloride is a potent, selective agonist of the 5-HT1A receptor, demonstrating high affinity for specific binding sites in the rat hippocampus (IC50 = 3 nM). Additionally, it acts as a selective antagonist of the dopamine D2 receptor with moderate affinity (IC50 = 0.1-1 μM). Xaliproden hydrochloride exhibits significant anti-depressant and anti-anxiety effects, making it a valuable compound for investigating therapeutic approaches in neurodegenerative disease research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 90494-79-4 |
| Applications | 5-HT1A Agonist |
| Formula | C24H23ClF3N |
| Molecular Weight | 417.89 |
| Synonyms | SR57746A; SR57746 hydrochloride |
| SMILES | FC(C1=CC(C2=CCN(CCC3=CC=C4C=CC=CC4=C3)CC2)=CC=C1)(F)F.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.