XE991 is a potent blocker of KCNQ (Kv7) channels, effectively inhibiting Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.3 (KCNQ3), and the M-current with IC50 values of 0.75 µM, 0.71 µM, 0.6 µM, and 0.98 µM, respectively. This selective inhibition makes XE991 a valuable tool for studying the physiological and pathophysiological roles of KCNQ channels in cells. It has applications in neurological research and the exploration of conditions related to ion channel dysfunction.
XE991 is a potent blocker of KCNQ (Kv7) channels, effectively inhibiting Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.3 (KCNQ3), and the M-current with IC50 values of 0.75 µM, 0.71 µM, 0.6 µM, and 0.98 µM, respectively. This selective inhibition makes XE991 a valuable tool for studying the physiological and pathophysiological roles of KCNQ channels in cells. It has applications in neurological research and the exploration of conditions related to ion channel dysfunction.
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