XL-281 is a potent and selective inhibitor of RAF kinase, demonstrating IC50 values of 2.6 nM for CRAF, 4.5 nM for B-RAF, and 6 nM for B-RAFV600E. This compound exhibits significant antitumor activity, making it a valuable tool for cancer research. It is particularly relevant for studies targeting RAF signaling pathways in various malignancies.
XL-281 is a potent and selective inhibitor of RAF kinase, demonstrating IC50 values of 2.6 nM for CRAF, 4.5 nM for B-RAF, and 6 nM for B-RAFV600E. This compound exhibits significant antitumor activity, making it a valuable tool for cancer research. It is particularly relevant for studies targeting RAF signaling pathways in various malignancies.
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