XL388

Catalog No.: A12395

mTOR inhibitor

XL388

XL388 Chemical Structure

CAS NO. 1251156-08-7

XL388 is a Novel Class of Highly Potent, Selective, ATP-Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR).

Availability: In stock

Package Price Qty
5 mg

Regular Price: $150.00

Special Price $135.00

10 mg

Regular Price: $250.00

Special Price $225.00

25 mg

Regular Price: $500.00

Special Price $450.00

100 mg

Regular Price: $1,000.00

Special Price $900.00

10mM * 1mL in DMSO

Regular Price: $259.00

Special Price $233.10

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

XL388 is a Novel Class of Highly Potent, Selective, ATP-Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR).
Targets
Target Value
mTORC1IC50: 8nM
mTORIC50: 9.9nM
mTORC2IC50: 166nM
PI3KαIC50: >3μM
CYP2C9IC50: 10.6μM
CYP2C8IC50: >20μM
CYP2D6IC50: >20μM
CYP3A4IC50: 24.6μM
In vitro (25°C) DMSO 23 mg/mL (50.49 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.95 mL 109.77 mL 219.54 mL
0.5 mM 4.39 mL 21.95 mL 43.91 mL
1 mM 2.2 mL 10.98 mL 21.95 mL
5 mM 0.44 mL 2.2 mL 4.39 mL

*The above data is based on the productmolecular weight 455.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12395
Actions Inhibitor
M. Wt 455.5
Formula C23H22FN3O4S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1251156-08-7
Synonyms XL 388, XL-388
SMILES CC1=C(C=CC(=C1F)S(=O)(=O)C)C(=O)N2CCOC3=C(C2)C=C(C=C3)C4=CN=C(C=C4)N

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