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mTOR inhibitor

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Catalog No. A12395

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
XL388 5mg A12395-5

Regular Price: $150.00

Special Price: $135.00

XL388 10mg A12395-10

Regular Price: $250.00

Special Price: $225.00

XL388 25mg A12395-25

Regular Price: $500.00

Special Price: $450.00

XL388 100mg A12395-100

Regular Price: $1,000.00

Special Price: $900.00

XL388 10mM * 1mL in DMSO A12395-10mM-D

Regular Price: $259.00

Special Price: $233.10

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

XL388 is a Novel Class of Highly Potent, Selective, ATP-Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR).


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Chemical Information

Catalog Num A12395
Actions Inhibitor
M. Wt 455.5
Formula C23H22FN3O4S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1251156-08-7
Synonyms XL 388, XL-388

Biological Activity

XL388 is a Novel Class of Highly Potent, Selective, ATP-Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR).
Target Value
mTORC1IC50: 8nM
mTORIC50: 9.9nM
mTORC2IC50: 166nM
PI3KαIC50: >3μM
CYP2C9IC50: 10.6μM
CYP2C8IC50: >20μM
CYP2D6IC50: >20μM
CYP3A4IC50: 24.6μM


Solubility (25°C) * In vitro DMSO 23 mg/mL (50.49 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.95 mL 109.77 mL 219.54mL
0.5 mM 4.39 mL 21.95 mL 43.91 mL
1 mM 2.2 mL 10.98 mL 21.95 mL
5 mM 0.44 mL 2.2 mL 4.39 mL

*The above data is based on the productmolecular weight 455.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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