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XL647 is an orally bioavailable small-molecule RTK inhibitor that binds to and inhibits several tyrosine receptor kinases that play major roles in tumor cell proliferation and tumor vascularization, including EGFR, HER2, ERBB2, VEGFR and EphB4.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.27 mL | 101.34 mL | 202.68 mL |
| 0.5 mM | 4.05 mL | 20.27 mL | 40.54 mL |
| 1 mM | 2.03 mL | 10.13 mL | 20.27 mL |
| 5 mM | 0.41 mL | 2.03 mL | 4.05 mL |
*The above data is based on the productmolecular weight 493.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11057 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 874286-84-7 |
| Formula | C24H27Cl2FN4O2 |
| M. Wt | 493.4 |
| Purity | >98% |
| Synonyms | XL 647, XL-647, EXEL-7647 |
| SMILES | CN1CCCC(CCC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=CC(=C(C(=C4)Cl)Cl)F)OC |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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