XL647 (Tesevatinib)

Catalog No.: A11057

EGFR, HER2 and VEGFR inhibitor

XL647 (Tesevatinib) Chemical Structure

CAS NO. 874286-84-7

XL647 is an orally bioavailable small-molecule RTK inhibitor that binds to and inhibits several tyrosine receptor kinases that play major roles in tumor cell proliferation and tumor vascularization, including EGFR, HER2, ERBB2, VEGFR and EphB4.

Availability: In stock

Package Price Qty
5 mg
$150.00
10 mg
$250.00
50 mg
$850.00
100 mg
$1,450.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

XL647 is an orally bioavailable small-molecule RTK inhibitor that binds to and inhibits several tyrosine receptor kinases that play major roles in tumor cell proliferation and tumor vascularization, including EGFR, HER2, ERBB2, VEGFR and EphB4.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.35 mL 101.75 mL 203.5 mL
0.5 mM 4.07 mL 20.35 mL 40.7 mL
1 mM 2.04 mL 10.18 mL 20.35 mL
5 mM 0.41 mL 2.04 mL 4.07 mL

*The above data is based on the productmolecular weight 491.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11057
Actions Inhibitor
M. Wt 491.4
Formula C24H25Cl2FN4O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 874286-84-7
Synonyms XL 647, XL-647, EXEL-7647
SMILES CN1CCCC(CCC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=CC(=C(C(=C4)Cl)Cl)F)OC

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