YGT-31 is a selective modulator of peroxisome proliferator-activated receptor gamma (PPARγ) with an IC50 of 1.72 μM and a Ki of 0.62 μM. This compound has demonstrated the ability to lower blood glucose levels and enhance insulin sensitivity in db/db mouse models of type 2 diabetes by inhibiting CDK5-mediated phosphorylation at Ser273 of PPARγ. Additionally, YGT-31 exhibits protective effects against hepatic steatosis in non-alcoholic fatty liver disease (NAFLD) models, highlighting its potential in metabolic disease research.
YGT-31 is a selective modulator of peroxisome proliferator-activated receptor gamma (PPARγ) with an IC50 of 1.72 μM and a Ki of 0.62 μM. This compound has demonstrated the ability to lower blood glucose levels and enhance insulin sensitivity in db/db mouse models of type 2 diabetes by inhibiting CDK5-mediated phosphorylation at Ser273 of PPARγ. Additionally, YGT-31 exhibits protective effects against hepatic steatosis in non-alcoholic fatty liver disease (NAFLD) models, highlighting its potential in metabolic disease research.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
