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YL0919, a novel antidepressant candidate with dual activity as a 5-HT1A receptor agonist and a selective serotonin reuptake inhibitor,the IC50 values of YL-0919 inhibiting the uptake of 5-HT into rat cerebral cortical synaptosomes and human recombinant cells were 1.78±0.34 nM and 1.93±0.18 nM respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 29.87 mL | 149.33 mL | 298.65 mL |
| 0.5 mM | 5.97 mL | 29.87 mL | 59.73 mL |
| 1 mM | 2.99 mL | 14.93 mL | 29.87 mL |
| 5 mM | 0.6 mL | 2.99 mL | 5.97 mL |
*The above data is based on the productmolecular weight 334.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16337 |
|---|---|
| Actions | Inhibitor, Agonist |
| M. Wt | 334.84 |
| Formula | C18H23N2O2Cl |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1339058-04-6 |
| Synonyms | YL-0919, YL 0919 |
| SMILES | O=C1C=CC=CN1CC2(O)CCN(CC3=CC=CC=C3)CC2.[H]Cl |
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