YM-543 is a selective inhibitor of the sodium-glucose cotransporter 2 (SGLT2), designed to reduce hyperglycemia in type 2 diabetes models. It exhibits potent inhibition of both human and mouse SGLT2 activities at nanomolar concentrations, ultimately increasing urinary glucose excretion and improving glucose tolerance. When administered orally, YM-543 maintains its therapeutic effects for over 12 hours and enhances the action of other antidiabetic agents, such as rosiglitazone or metformin, without affecting blood glucose levels in non-diabetic models. This specificity underscores its potential utility in diabetic research and therapeutic strategies.
YM-543 is a selective inhibitor of the sodium-glucose cotransporter 2 (SGLT2), designed to reduce hyperglycemia in type 2 diabetes models. It exhibits potent inhibition of both human and mouse SGLT2 activities at nanomolar concentrations, ultimately increasing urinary glucose excretion and improving glucose tolerance. When administered orally, YM-543 maintains its therapeutic effects for over 12 hours and enhances the action of other antidiabetic agents, such as rosiglitazone or metformin, without affecting blood glucose levels in non-diabetic models. This specificity underscores its potential utility in diabetic research and therapeutic strategies.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
