YT 6-2 is an autophagy-targeting ligand (ATL) that targets p62/SQSTM1, functioning as a control for the AUTAC mechanism. This compound plays a crucial role in enhancing the degradation of the androgen receptor (AR), leading to a reduction in nuclear AR levels and subsequent downregulation of AR target gene expression, including AR-v7. Additionally, YT 6-2 demonstrates efficacy against common AR mutants, making it a valuable tool for research in prostate cancer (PCa) therapies and the study of AR pathway modulation.
YT 6-2 is an autophagy-targeting ligand (ATL) that targets p62/SQSTM1, functioning as a control for the AUTAC mechanism. This compound plays a crucial role in enhancing the degradation of the androgen receptor (AR), leading to a reduction in nuclear AR levels and subsequent downregulation of AR target gene expression, including AR-v7. Additionally, YT 6-2 demonstrates efficacy against common AR mutants, making it a valuable tool for research in prostate cancer (PCa) therapies and the study of AR pathway modulation.
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