YZ-836P is a selective inhibitor of Protein arginine methyltransferase 5 (PRMT5), promoting its ubiquitination and subsequent degradation through a cereblon (CRBN)-dependent mechanism. This reduction in PRMT5 levels results in decreased expression of its downstream target, KLF5, leading to G1 phase cell cycle arrest and apoptosis in triple-negative breast cancer cells. YZ-836P demonstrates significant cytotoxicity against these cells and effectively inhibits the growth of patient-derived organoids as well as xenografts in nude mice, making it a valuable tool for research in triple-negative breast cancer.
YZ-836P is a selective inhibitor of Protein arginine methyltransferase 5 (PRMT5), promoting its ubiquitination and subsequent degradation through a cereblon (CRBN)-dependent mechanism. This reduction in PRMT5 levels results in decreased expression of its downstream target, KLF5, leading to G1 phase cell cycle arrest and apoptosis in triple-negative breast cancer cells. YZ-836P demonstrates significant cytotoxicity against these cells and effectively inhibits the growth of patient-derived organoids as well as xenografts in nude mice, making it a valuable tool for research in triple-negative breast cancer.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
