Z21115 is an orally active inhibitor of phosphodiesterase 4 (PDE4), specifically targeting PDE4D7 with an IC50 of 10.5 nM. This compound effectively inhibits the lipopolysaccharide-induced expression of pro-inflammatory cytokines IL-6, TNF-α, and iNOS. Z21115 demonstrates notable anti-inflammatory activity in dextran sulfate sodium (DSS)-induced mouse colitis models while exhibiting minimal toxicity at doses up to 1 g/kg. This makes Z21115 a valuable reagent for research on inflammatory diseases.
Z21115 is an orally active inhibitor of phosphodiesterase 4 (PDE4), specifically targeting PDE4D7 with an IC50 of 10.5 nM. This compound effectively inhibits the lipopolysaccharide-induced expression of pro-inflammatory cytokines IL-6, TNF-α, and iNOS. Z21115 demonstrates notable anti-inflammatory activity in dextran sulfate sodium (DSS)-induced mouse colitis models while exhibiting minimal toxicity at doses up to 1 g/kg. This makes Z21115 a valuable reagent for research on inflammatory diseases.
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