ZCZ011 is a potent positive allosteric modulator of the cannabinoid 1 (CB1) receptor. It enhances the binding of CP55,940 to CB1 receptors and stimulates anandamide (AEA)-mediated GTPγS binding in mouse brain membranes. ZCZ011 also promotes β-arrestin recruitment and ERK phosphorylation in human CB1 cells, making it a valuable tool for investigating mechanisms associated with neuropathic and inflammatory pain.
ZCZ011 is a potent positive allosteric modulator of the cannabinoid 1 (CB1) receptor. It enhances the binding of CP55,940 to CB1 receptors and stimulates anandamide (AEA)-mediated GTPγS binding in mouse brain membranes. ZCZ011 also promotes β-arrestin recruitment and ERK phosphorylation in human CB1 cells, making it a valuable tool for investigating mechanisms associated with neuropathic and inflammatory pain.
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