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- Muthulakshmi S, .et al. Mycotoxin zearalenone induced gonadal impairment and altered gene expression in the hypothalamic-pituitary-gonadal axis of adult female zebrafish (Danio rerio), J Appl Toxicol, 2018, Nov;38(11):1388-1397 PMID: 29923290
Biological Activity
Zearalenone is a phytoestrogenic mycotoxin usually produced by Fusarium species, is shown to be a cytotoxic compound, but alos binds to the estrogen receptor (ER) (IC50 values are 166 and 240 nM for ERβ and ERα respectively) and was found to stimulate the transcriptional activity of both subtypes at concentrations between 1 - 10 nM.
| In vitro | DMSO | 56 mg/mL (175.9 mM) | |
| Water | Insoluble | ||
| Ethanol | 56 mg/mL (175.9 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 31.41 mL | 157.05 mL | 314.11 mL |
| 0.5 mM | 6.28 mL | 31.41 mL | 62.82 mL |
| 1 mM | 3.14 mL | 15.71 mL | 31.41 mL |
| 5 mM | 0.63 mL | 3.14 mL | 6.28 mL |
*The above data is based on the productmolecular weight 318.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13740 |
|---|---|
| CAS No. | 17924-92-4 |
| Formula | C18H22O5 |
| M. Wt | 318.36 |
| Purity | >98% |
| SMILES | C[C@H]1CCCC(=O)CCC/C=C/C2=CC(=CC(=C2C(=O)O1)O)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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