Zelenirstat is a potent dual inhibitor of N-myristoyltransferase (NMT), exhibiting IC50 values of 5 nM for NMT1 and 8 nM for NMT2. This orally active small molecule induces apoptosis in cancer cells and demonstrates anti-cancer activity by inhibiting early B cell receptor (BCR) signaling. Zelenirstat is a valuable tool for investigating the mechanisms underlying malignant lymphoma and other related malignancies.
Zelenirstat is a potent dual inhibitor of N-myristoyltransferase (NMT), exhibiting IC50 values of 5 nM for NMT1 and 8 nM for NMT2. This orally active small molecule induces apoptosis in cancer cells and demonstrates anti-cancer activity by inhibiting early B cell receptor (BCR) signaling. Zelenirstat is a valuable tool for investigating the mechanisms underlying malignant lymphoma and other related malignancies.
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