ZM 336372

Name: ZM 336372
Brand: Adooq Bioscience
SKU: A11077
Rating: 100 (268 reviews)

Catalog No.: A11077

C-Raf inhibitor

ZM 336372 Chemical Structure

CAS NO. 208260-29-1

ZM 336372 is a potent ATP-competitive inhibitor of Raf-1 in vitro (IC50 = 70 nM) with the paradoxical effect of inducing >100-fold activation of Raf-1 in whole cells.

Availability: In stock

Package	Price	Qty
5 mg	$40.00
10 mg	$70.00
50 mg	$200.00
100 mg	$350.00
10mM * 1mL in DMSO	$60.00
Custom Size	Get quote

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Biological Activity

ZM 336372 is a potent ATP-competitive inhibitor of Raf-1 in vitro (IC50 = 70 nM) with the paradoxical effect of inducing >100-fold activation of Raf-1 in whole cells.

Targets

C-Raf
70 nM

Solubility *

In vitro	DMSO	75 mg/mL (192.58 mM)
	Water	Insoluble
	Ethanol	2 mg/mL (5.13 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.67 mL	128.37 mL	256.74 mL
0.5 mM	5.13 mL	25.67 mL	51.35 mL
1 mM	2.57 mL	12.84 mL	25.67 mL
5 mM	0.51 mL	2.57 mL	5.13 mL

*The above data is based on the productmolecular weight 389.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A11077
Actions	Inhibitor
CAS No.	208260-29-1
Formula	C23H23N3O3
M. Wt	389.5
Purity	>98%
Synonyms	ZM-336372, ZM336372
SMILES	CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)N(C)C)NC(=O)C3=CC=C(C=C3)O
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.