Zonisamide-d4 is a deuterated derivative of Zonisamide, primarily acting as an inhibitor of carbonic anhydrase (CA) enzymes, specifically targeting human mitochondrial isozyme hCA II and hCA V with inhibition constants of 35.2 nM and 20.6 nM, respectively. This stable isotope is valuable in pharmacokinetic studies and isotopic labeling experiments to enhance the understanding of Zonisamide's pharmacodynamics and therapeutic efficacy. Its applications extend to research on epilepsy, seizure disorders, and Parkinson's disease.
Zonisamide-d4 is a deuterated derivative of Zonisamide, primarily acting as an inhibitor of carbonic anhydrase (CA) enzymes, specifically targeting human mitochondrial isozyme hCA II and hCA V with inhibition constants of 35.2 nM and 20.6 nM, respectively. This stable isotope is valuable in pharmacokinetic studies and isotopic labeling experiments to enhance the understanding of Zonisamide's pharmacodynamics and therapeutic efficacy. Its applications extend to research on epilepsy, seizure disorders, and Parkinson's disease.
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