Zonisamide is an orally active inhibitor of carbonic anhydrases, demonstrating Ki values of 35.2 nM for human carbonic anhydrase II and 20.6 nM for human carbonic anhydrase V. This compound exhibits neuroprotective properties by promoting anti-apoptotic mechanisms and enhancing manganese superoxide dismutase (MnSOD) expression. Additionally, Zonisamide has been shown to upregulate Hrd1 expression, which contributes to improved cardiac function in animal models of cardiac hypertrophy. Research applications include investigations into seizures, Parkinson's disease, and cardiac hypertrophy.
Zonisamide is an orally active inhibitor of carbonic anhydrases, demonstrating Ki values of 35.2 nM for human carbonic anhydrase II and 20.6 nM for human carbonic anhydrase V. This compound exhibits neuroprotective properties by promoting anti-apoptotic mechanisms and enhancing manganese superoxide dismutase (MnSOD) expression. Additionally, Zonisamide has been shown to upregulate Hrd1 expression, which contributes to improved cardiac function in animal models of cardiac hypertrophy. Research applications include investigations into seizures, Parkinson's disease, and cardiac hypertrophy.
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