Aprepitant (MK-0869)

Catalog No.: A10083
neurokinin-1 receptor antagonist

Aprepitant is classified as an NK1 antagonist. Aprepitant has been shown to inhibit both the acute and delayed emesis induced by cytotoxic chemotherapeutic drugs by blocking substance P landing on receptors in the brains neurons. It has also been shown to increase the activity of the 5-HT3 receptor antagonists ondansetron and the corticosteroid dexamethasone, which are also used to prevent nausea and vomiting caused by chemotherapy.

Grouped product items
Product Name Price Stock Qty
Aprepitant 2mg
$30.00
In stock
Aprepitant 5mg
$50.00
In stock
Aprepitant 10mg
$60.00
In stock
Aprepitant 25mg
$70.00
In stock
Aprepitant (MK-0869) 10mM * 1mL in DMSO
$139.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500

Important Notice: For research use only. We do not sell to patients.

Not your Region? View all Distributors

Adooq Products cited in reputable paper
Adooq's Aprepitant (MK-0869) has been cited by 2 publications
  • Maya Tokumoto, .et al. , Connect Tissue Res, 2022, Jul 20;1-11 PMID: 35856812
  • Kodji X, .et al. , FASEB J, 2018, Sep 11:fj201800395RR PMID: 30204499
  • Biological Activity
    Discription

    Aprepitant is classified as an NK1 antagonist. Aprepitant has been shown to inhibit both the acute and delayed emesis induced by cytotoxic chemotherapeutic drugs by blocking substance P landing on receptors in the brains neurons. It has also been shown to increase the activity of the 5-HT3 receptor antagonists ondansetron and the corticosteroid dexamethasone, which are also used to prevent nausea and vomiting caused by chemotherapy.

    Targets
    Target Value
    Product Information
    Catalog Num A10083
    Formula C23H21F7N4O3
    Molecular Weight 534.4
    CAS Number 170729-80-3
    SMILES C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NC(=O)NN3)C4=CC=C(C=C4)F
    Synonyms L-754030, Emend
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 96 mg/mL (179.63 mM)
    Water Insoluble
    Ethanol 14 mg/mL (26.19 mM)
    In vivo 5% DMSO+corn oil 12 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 18.71 mL 93.56 mL 187.13 mL
    0.5 mM 3.74 mL 18.71 mL 37.43 mL
    1 mM 1.87 mL 9.36 mL 18.71 mL
    5 mM 0.37 mL 1.87 mL 3.74 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

    • Mass

      Concentration

      Volume

      Molecular Weight

    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

    • C1

      V1

      C2

      V2

    • Calculator Reset
    Keywords: buy Aprepitant (MK-0869) | Aprepitant (MK-0869) Supplier | purchase Aprepitant (MK-0869) | Aprepitant (MK-0869) cost | Aprepitant (MK-0869) manufacturer | order Aprepitant (MK-0869) | Aprepitant (MK-0869) distributor | buy 170729-80-3 | 170729-80-3 Supplier | purchase 170729-80-3 | 170729-80-3 cost | 170729-80-3 manufacturer | order 170729-80-3 | 170729-80-3 distributor