BX-795

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PDK-1 inhibitor

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Catalog No. A11148

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
BX-795 10mg A11148-10

Regular Price: $120.00

Special Price: $102.00

BX-795 25mg A11148-25

Regular Price: $250.00

Special Price: $212.50

BX-795 50mg A11148-50

Regular Price: $420.00

Special Price: $357.00

BX-795 100mg A11148-100

Regular Price: $800.00

Special Price: $680.00

BX-795 10mM * 1mL in DMSO A11148-10mM-D

Regular Price: $130.00

Special Price: $110.50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

BX-795 is a potent PDK1 inhibitor that blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induced apoptosis.

BX-795

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Chemical Information

Catalog Num A11148
Actions Inhibitor
M. Wt 591.5
Formula C23H26IN7O2S
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 702675-74-9
Synonyms BX795
SMILES code C1CCN(C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)NCCCNC(=O)C4=CC=CS4)I
Chemical Name N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide

Biological Activity

Description
BX-795 is a potent PDK1 inhibitor that blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induced apoptosis.
Targets
Target Value
TBK1/IKK?
PDK-1IC50: 6nM
c-KitIC50: 320nM
CDK2/CyclinEIC50: 430nM
Chk1IC50: 510nM
GSK-3βIC50: 620nM
PKAIC50: 840nM
KDRIC50: 1.1μM
T-FynIC50: 6.4μM
PKCIC50: 9.3μM
EGFRIC50: >10μM
Insulin ReceptorIC50: >10μM

Solubility

Solubility (25°C) * In vitro DMSO 100 mg/mL (169.07 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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