Daphnetin

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EGFR, PKA,PKC inhibitor

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Catalog No. A10286

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Daphnetin 10mg A10286-10

Regular Price: $50.00

Special Price: $42.50

Daphnetin 25mg A10286-25

Regular Price: $100.00

Special Price: $85.00

Daphnetin 50mg A10286-50

Regular Price: $180.00

Special Price: $153.00

Daphnetin 100mg A10286-100

Regular Price: $320.00

Special Price: $272.00

Daphnetin 10mM * 1mL in DMSO A10286-10mM-D

Regular Price: $68.00

Special Price: $57.80

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Daphnetin is a coumarin analog that acts as an inhibitor of several protein kinases. It inhibits EGFR kinase (IC50 = 7.67 µM), PKA (IC50 = 9.33 µM), and PKC (IC50 = 25 µM), in vitro. The inhibition of EGFR kinase by daphnetin was competitive to ATP and non-competitive to the peptide substrate. Also acts as a potent antioxidant and anti-malarial agent.

Daphnetin

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Chemical Information

Catalog Num A10286
Actions Inhibitor
M. Wt 178.1
Formula C9H6O4
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 486-35-1
Synonyms 7,8-dihydroxycoumarin
SMILES code C1=CC(=C(C2=C1C=CC(=O)O2)O)O
Chemical Name 7,8-dihydroxy-2H-chromen-2-one

Biological Activity

Description
Daphnetin is a coumarin analog that acts as an inhibitor of several protein kinases. It inhibits EGFR kinase (IC50 = 7.67 µM), PKA (IC50 = 9.33 µM), and PKC (IC50 = 25 µM), in vitro. The inhibition of EGFR kinase by daphnetin was competitive to ATP and non-competitive to the peptide substrate. Also acts as a potent antioxidant and anti-malarial agent.
Targets
EGFR PKA PKC
7.67 μM9.33 μM25.01 μM

Solubility

Solubility (25°C)* In vitro DMSO 35 mg/mL (196.47 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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