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Gemcitabine HCl (Gemzar)

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DNA/RNA Synthesis inhibitor

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Catalog No. A10423

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Gemcitabine HCl 25mg A10423-25

Regular Price: $30.00

Special Price: $24.00

Gemcitabine HCl 50mg A10423-50

Regular Price: $40.00

Special Price: $32.00

Gemcitabine HCl 100mg A10423-100

Regular Price: $50.00

Special Price: $40.00

Gemcitabine HCl 200mg A10423-200

Regular Price: $60.00

Special Price: $48.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Gemcitabine (Gemzar) is a newer chemotherapy drug acting by replacing one of the building blocks of nucleic acids during DNA replication in cancer cells, preventing tumor growth.

Gemcitabine HCl (Gemzar)

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Chemical Information

Catalog Num A10423
Actions Inhibitor
M. Wt 299.7
Formula C9H11F2N3O4.HCI
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 122111-03-9
Synonyms N/A
SMILES code C1=CN(C(=O)N=C1N)[[email protected]]2C([[email protected]@H]([[email protected]](O2)CO)O)(F)F.Cl
Chemical Name 4-Amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-pyrimidin-2-one hydrochloride

Biological Activity

Description
Gemcitabine (Gemzar) is a newer chemotherapy drug acting by replacing one of the building blocks of nucleic acids during DNA replication in cancer cells, preventing tumor growth.
Targets
DNA synthesis (Capan2 cells) DNA synthesis (BxPC3 cells) DNA synthesis (MIAPaCa2 cells) DNA synthesis (PANC1 cells)
12 nM18 nM40 nM50 nM

Solubility

Solubility (25°C) * In vitro DMSO <1 mg/mL (<1 mM)
Water 19 mg/mL (63.4 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 20 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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