Gemcitabine

Catalog No.: A11434

DNA synthesis inhibitor

Gemcitabine

Gemcitabine Chemical Structure

CAS NO. 95058-81-4

Gemcitabine (LY 188011) is a DNA synthesis inhibitor which inhibits the growth of BxPC-3, Mia Paca-2, PANC-1, PL-45 and AsPC-1 cells with IC50s of 37.6, 42.9, 92.7, 89.3 and 131.4 nM, respectively.

Availability: In stock

Package Price Qty
100 mg
$45.00
500 mg
$135.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Yi-Ru Pan, .et al. ATM Inhibitor Suppresses Gemcitabine-Resistant BTC Growth in a Polymerase θ Deficiency-Dependent Manner, Biomolecules, 2020, Nov 9;10(11):1529 PMID: 33182492

Biological Activity

Gemcitabine (LY 188011) is a DNA synthesis inhibitor which inhibits the growth of BxPC-3, Mia Paca-2, PANC-1, PL-45 and AsPC-1 cells with IC50s of 37.6, 42.9, 92.7, 89.3 and 131.4 nM, respectively.
In vitro (25°C) DMSO 47 mg/mL (178.56 mM)
Water Warmed: 47 mg/mL (178.56 mM)
Ethanol Insoluble
In vivo water (warmed) 49 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 37.99 mL 189.97 mL 379.94 mL
0.5 mM 7.6 mL 37.99 mL 75.99 mL
1 mM 3.8 mL 19 mL 37.99 mL
5 mM 0.76 mL 3.8 mL 7.6 mL

*The above data is based on the productmolecular weight 263.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11434
Actions Inhibitor
CAS No. 95058-81-4
Formula C9H11F2N3O4
M. Wt 263.2
Purity >98%
Synonyms LY 188011, LY188011, LY-188011
SMILES O=C1N(C=CC(N)=N1)[[email protected]]2C(F)([[email protected]@H]([[email protected]](O2)CO)O)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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