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$0.00 - Yi-Ru Pan, .et al. ATM Inhibitor Suppresses Gemcitabine-Resistant BTC Growth in a Polymerase θ Deficiency-Dependent Manner, Biomolecules, 2020, Nov 9;10(11):1529 PMID: 33182492
Biological Activity
Gemcitabine (LY 188011) is a DNA synthesis inhibitor which inhibits the growth of BxPC-3, Mia Paca-2, PANC-1, PL-45 and AsPC-1 cells with IC50s of 37.6, 42.9, 92.7, 89.3 and 131.4 nM, respectively.
| In vitro (25°C) | DMSO | 47 mg/mL (178.56 mM) | |
| Water | Warmed: 47 mg/mL (178.56 mM) | ||
| Ethanol | Insoluble | ||
| In vivo | water (warmed) | 49 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 37.99 mL | 189.97 mL | 379.94 mL |
| 0.5 mM | 7.6 mL | 37.99 mL | 75.99 mL |
| 1 mM | 3.8 mL | 19 mL | 37.99 mL |
| 5 mM | 0.76 mL | 3.8 mL | 7.6 mL |
*The above data is based on the productmolecular weight 263.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11434 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 95058-81-4 |
| Formula | C9H11F2N3O4 |
| M. Wt | 263.2 |
| Purity | >98% |
| Synonyms | LY 188011, LY188011, LY-188011 |
| SMILES | O=C1N(C=CC(N)=N1)[[email protected]]2C(F)([[email protected]@H]([[email protected]](O2)CO)O)F |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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