(+)-JQ1
(+)-JQ1 is a potent, high affinity, selective BET bromodomain inhibitor.
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Research use only. We do not sell to patients.
Other Forms of (+)-JQ1
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Adooq Products cited in reputable paper
Adooq's (+)-JQ1 has been cited by 13 publications
- Jiang Zhou, .et al. , Neoplasia, 2025, Oct:68:101223 PMID: 40850308
- Kei Taga, .et al. , Microbiol Immunol, 2024, Mar;68(3):90-99 PMID: 38244193
- Deeksha Sharma, .et al. , Breast Cancer Res, 2023, Nov 15;25(1):144 PMID: 37968653
- Adriana K Alexander, .et al. , Nat Commun, 2023, Mar 29;14(1):1753 PMID: 36990976
- Haruki Kitamura, .et al. , Biochem Biophys Res Commun, 2023, Jan 22;641:139-147 PMID: 36527748
- Gerald Thiel, .et al. , Pharmaceuticals (Basel), 2022, Jul 10;15(7):846 PMID: 35890145
- Selase D Deletsu, .et al. , Biochem Biophys Res Commun, 2021, Aug 27;567:106-111 PMID: 34146904
- Cole Schonhofer, .et al. , Biochem Pharmacol, 2021, Apr;186:114462 PMID: 33577894
- Nandini Verma, .et al. , Sci Adv, 2020, 6 : eaba8968
- Kuo MT, .et al. , Transl Oncol, 2020, 13(2):355-364 PMID: 31887630
- Rao Z, .et al. , J Immunol, 2019, Aug 15;203(4):1031-1043 PMID: 31300512
- A Carrer, .et al. , Cancer Discov, 2019, Jan 9. pii: CD-18-0567 PMID: 30626590
- Clocchiatti A, .et al. , J Clin Invest, 2018, Dec 3;128(12):5531-5548 PMID: 30395538
Biological Activity
| Description | (+)-JQ1 is a potent, high affinity, selective BET bromodomain inhibitor. | |||||
|---|---|---|---|---|---|---|
| Cell Research |
|
Product Information
| Catalog Num | A12729 |
|---|---|
| Formula | C23H25ClN4O2S |
| Molecular Weight | 456.99 |
| CAS Number | 1268524-70-4 |
| SMILES | CC1=C(SC2=C1C(=N[C@H](C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Solubility
| In vitro (25°C) | DMSO | Warmed: 90 mg/mL (196.93 mM) | |
| Water | Insoluble | ||
| Ethanol | 90 mg/mL | ||
| In vivo | 2% DMSO+30% PEG 300+5% Tween 80+ddH2O | 4 mg/mL | |
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.88 mL | 109.41 mL | 218.82 mL |
| 0.5 mM | 4.38 mL | 21.88 mL | 43.76 mL |
| 1 mM | 2.19 mL | 10.94 mL | 21.88 mL |
| 5 mM | 0.44 mL | 2.19 mL | 4.38 mL |
Useful Calculator
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
Please check COA/MSDS for correct molecular weight.
Calculate the dilution required to prepare a stock solution.This equation is commonly abbreviated as: C1V1 = C2V2
