KU-55933

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ATM inhibitor

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Catalog No. A10506

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
KU-55933 5mg A10506-5

Regular Price: $40.00

Special Price: $32.00

KU-55933 10mg A10506-10

Regular Price: $60.00

Special Price: $48.00

KU-55933 50mg A10506-50

Regular Price: $200.00

Special Price: $160.00

KU-55933 100mg A10506-100

Regular Price: $350.00

Special Price: $280.00

KU-55933 10mM * 1mL in DMSO A10506-10mM-D

Regular Price: $60.00

Special Price: $48.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

KU-55933 is an ATM inhibitor by suppressing cell proliferation and induces apoptosis by blocking Akt in cancer cells with overactivated Akt.

KU-55933

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Chemical Information

Catalog Num A10506
Actions Inhibitor
M. Wt 395.5
Formula C21H17NO3S2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 587871-26-9
Synonyms KU55933
SMILES code C1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4
Chemical Name 2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one

Biological Activity

Description
KU-55933 is an ATM inhibitor by suppressing cell proliferation and induces apoptosis by blocking Akt in cancer cells with overactivated Akt.
Targets
Target Value
ATMIC50: 12.9nM
DNA-PKIC50: 2.5μM
mTORIC50: 9.3μM
PI3KIC50: 16.6μM
ATRIC50: >100μM
PI4KIC50: >100μM

Solubility

Solubility (25°C) * In vitro DMSO 33 mg/mL (83.44 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 5% DMSO and 47.5% PEG300 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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