• Sign In
  • FAQ
  • Create an Account
  • 866-930-6790
Currency
USD
Toggle Nav
My Cart
Search
Menu
Account
Settings
Currency
USD

ATM/ATR

26 Items

per page
Set Descending Direction
Catalog No.
Product Name
Application
Product Information
Product Citation
  1. A10133
    BEZ235 (NVP-BEZ235, Dactolisib)

    PI3K/mTOR Inhibitor

    BEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes.
    Quick View
  2. A10506
    KU-55933

    ATM inhibitor

    KU-55933 is an ATM inhibitor by suppressing cell proliferation and induces apoptosis by blocking Akt in cancer cells with overactivated Akt.
    Quick View
  3. A10507
    KU-60019

    ATM Inhibitor

    KU-60019 is a potent and specific ATM inhibitor with IC50 of 6.3 nM.
    Quick View
  4. A11086
    CP-466722

    ATM inhibitor

    CP-466722 is a specific ATM inhibitor that inhibits cellular ATM-dependent phosphorylation events and disruption of ATM function resulted in characteristic cell cycle checkpoint defects.
    Quick View
  5. A11161
    Wortmannin

    PI3K inhibitor

    Wortmannin is a potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC50 = 2 - 4 nM) which also potently inhibits polo-like kinase 1 (PLK1) (IC50 = 5.8 nM).

    Quick View
  6. A11586
    Torin 2

    mTOR inhibitor

    Torin 2 is a potent and selective mTOR inhibitor (IC50 = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively).
    Quick View
  7. A11605
    VE-821

    ATM/ATR inhibitor

    VE-821 is a potent and selective inhibitor of protein kinase ATR.
    Quick View
  8. A11991
    Schisandrin B

    Schisandrin B is the most abundant dibenzocyclooctadiene isolated from the fruit of Schisandra chinensis (Turcz) Baillon or Wu-Wei-Zi (transliterally meaning "the fruit of five tastes" in Chinese), which is a commonly used tonic herb in Chinese medicine, particularly for the treatment of liver ailments.
    Quick View
  9. A13191
    CGK 733

    ATM/ATR inhibitor

    CGK733 is a selective inhibitor of ATR and ATM kinases. Induces cell death in prematurely senescent breast cancer cells.
    Quick View
  10. A13205
    AZ-20

    ATR kinase inhibitor

    AZ20 is a potent and selective inhibitor of ATR with an IC50 value of 5 nM.
    Quick View
  11. A13289
    VE-822

    ATR inhibitor

    VE-822 is an potent ATR inhibitor.
    Quick View
  12. A13328
    ETP-46464

    ATR inhibitor

    ETP-46464 is a potent and selective inhibitor of ATR with IC50 of 25 nM.
    Quick View
  13. A14136
    NU6027

    ATR/CDK inhibitor

    NU6027 is a potent inhibitor of cellular ATR activity (IC(50)=6.7 μM) and enhanced hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner.
    Quick View
  14. A15794
    AZD6738 (Ceralasertib)

    ATR inhibitor

    AZD6738 is a potent inhibitor of ATR kinase activity with an IC50 of 1 nM against the isolated enzyme and 74 nM against ATR kinase-dependent CHK1 phosphorylation in cells.
    Quick View
  15. A15842
    Mirin

    ATM Inhibitor

    Mirin prevents ATM activation in response to double strand breaks (IC50 = 12 uM) and induces G2 cell cycle arrest.
    Quick View
  16. A16419
    AZD0156

    ATM inhibitor

    AZD0156 is a potent and selective inhibitors of ATM kinase, with potential chemo-/radio-sensitizing and antineoplastic activities.
    Quick View
  17. A16445
    Chloroquine Phosphate

    Chloroquine phosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator.
    Quick View
  18. A16798
    AZD1390

    ATM inhibitor

    AZD1390 is a first-in-class orally available and CNS penetrant ATM inhibitor with an IC50 of 0.78 nM in cells and >10,000-fold selectivity over closely related members of the PIKK family of enzymes and excellent selectivity across a broad panel of kinases.
    Quick View
  19. A16813
    AZ31

    ATM inhibitor

    AZ31 is a selective and novel ATM inhibitor with an IC50 of <0.0012 μM. It shows excellent selectivity over closely related enzymes (>500 fold selective over DNA-PK and PI3Kα and >1000 fold selective over mTOR, PI3Kβ and PI3Kγ).
    Quick View
  20. A16814
    AZ32

    ATM inhibitor

    AZ32 is a specific inhibitor of the ATM kinase that possesses good BBB penetration in mouse with an IC50 value of <0.0062 μM for ATM enzyme. It shows adequate selectivity over ATR and also has high cell permeability.
    Quick View
  21. A19454
    BAY-1895344

    ATR inhibitor

    BAY-1895344 is a potent, orally available and selective ATR inhibitor, with IC50 of 7 nM. Anti-tumor activity.
    Quick View
  22. A19874
    ATR inhibitor 1

    ATR inhibitor

    ATR inhibitor 1 is a ATR inhibitor extracted from patent WO2015187451A1, compound I-l, has a Ki value below 1 ?μ.
    Quick View
  23. A19931
    ATM Inhibitor-1

    ATM inhibitor

    ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibitor, with an IC50 of 0.7 nM.
    Quick View
  24. A20928
    KU 59403

    ATM inhibitor

    KU 59403 is a potent ATM inhibitor, with an IC50 of 3 nM.
    Quick View
  25. A22162
    ATR inhibitor 2

    ATR inhibitor

    ATR inhibitor 2 is an ATP-competitive, orally active, and selective ATR inhibitor, with a Ki of <150 pM.
    Quick View
  26. A21870
    Camonsertib

    ATR inhibitor

    Camonsertib is an orally active, selective ATR kinase inhibitor (ATRi) with an IC50 of 1.00 nM in biochemical assays. 

    Quick View

26 Items

per page
Set Descending Direction