Pemetrexed (Alimta)

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Catalog No. A10707

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Pemetrexed 10mg A10707-10

Regular Price: $70.00

Special Price: $59.50

Pemetrexed 50mg A10707-50

Regular Price: $200.00

Special Price: $170.00

Pemetrexed 100mg A10707-100

Regular Price: $350.00

Special Price: $297.50

Pemetrexed 200mg A10707-200

Regular Price: $600.00

Special Price: $510.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Pemetrexed is chemically similar to folic acid and is in the class of chemotherapy drugs called folate antimetabolites. It works by inhibiting three enzymes used in purine and pyrimidine synthesis—thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase.

Pemetrexed (Alimta)

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Chemical Information

Catalog Num A10707
Actions N/A
M. Wt 471.4
Formula C20H19N5Na2O6
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 150399-23-8
Synonyms LY-231514, LY231514
SMILES code C1=CC(=CC=C1CCC2=CNC3=C2C(=O)N=C(N3)N)C(=O)N[[email protected]@H](CCC(=O)[O-])C(=O)[O-].[Na+].[Na+]
Chemical Name (2S)-2-{[4-[2-(2-amino-4-oxo-1,7-dihydro pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino} pentanedioic acid

Biological Activity

Description
Pemetrexed is chemically similar to folic acid and is in the class of chemotherapy drugs called folate antimetabolites. It works by inhibiting three enzymes used in purine and pyrimidine synthesis—thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase.
Targets
TS (Cell-free assay) DHFR (Cell-free assay) GARFT (Cell-free assay)
1.3 nM(Ki)7.2 nM(Ki)65 nM(Ki)

Solubility

Solubility (25°C) * In vitro DMSO <1 mg/mL (<1 mM)
Water 94 mg/mL (199.41 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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