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  1. DHFR inhibitor

    Methotrexate is a cytotoxic agent that inhibits thymidylate synthetase and de novo purine synthesis.
  2. DHFR inhibitor

    NSC 131463 is a dihydrofolate reductase potent inhibitor with an IC50 of 1 nM.
  3. DHFR inhibitor

    Pemetrexed disodium is chemically similar to folic acid and is in the class of chemotherapy drugs called folate antimetabolites. It works by inhibiting three enzymes used in purine and pyrimidine synthesis?€?thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase.
  4. DHFR inhibitor

    Pralatrexate is an antifolate (a folate analogue metabolic inhibitor) designed to accumulate preferentially in cancer cells.
  5. Aminopterin is an antineoplastic drug. It works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase.
  6. DHFR inhibitor

    Pemetrexed is a novel antifolate with multiple targets
  7. Trimetrexate is a quinazoline derivative. It is a dihydrofolate reductase inhibitor.
  8. DHFR inhibitor

    Pemetrexed is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.
  9. DHFR inhibitor

    Diaveridine (EGIS-5645) is a dihydrofolate reductase (DHFR) inhibitor with a Ki of 11.5 nM for the wild type DHFR and also an antibacterial agent.
  10. DHFR inhibitor

    WR99210 is a effective inhibitor of dihydrofolate reductase (DHFR) with an IC50 of <0.075 nM. WR99210 is effective against the most pyrimethamine-resistant Plasmodium falciparum strains.

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