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Biological Activity
Pemetrexed is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.
Targets
| TS | TS | DHFR | DHFR | GARFT |
| 1.3 nM | 1.3 nM(Ki) | 7.2 nM | 7.2 nM(Ki) | 65 nM(Ki) |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 9.68 mL | 48.41 mL | 96.82 mL |
| 0.5 mM | 1.94 mL | 9.68 mL | 19.36 mL |
| 1 mM | 0.97 mL | 4.84 mL | 9.68 mL |
| 5 mM | 0.19 mL | 0.97 mL | 1.94 mL |
*The above data is based on the productmolecular weight 1032.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15207 |
|---|---|
| CAS No. | 357166-30-4 |
| Formula | C40H48N10Na4O17 |
| M. Wt | 1032.8 |
| Purity | >98% |
| Synonyms | Pemetrexed sodium hydrate (1:2:2.5) |
| SMILES | C1=CC(=CC=C1CCC2=CNC3=C2C(=O)N=C(N3)N)C(=O)NC(CCC(=O)[O-])C(=O)[O-].C1=CC(=CC=C1CCC2=CNC3=C2C(=O)N=C(N3)N)C(=O)NC(CCC(=O)[O-])C(=O)[O-].O.O.O.O.O.[Na+].[Na+].[Na+].[Na+] |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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