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Pemetrexed disodium hemipenta hydrate

Catalog No.: A15207

Pemetrexed disodium hemipenta hydrate

Pemetrexed disodium hemipenta hydrate Chemical Structure

CAS NO. 357166-30-4

Pemetrexed is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.

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1000 mg
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5000 mg
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Biological Activity

Pemetrexed is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.
Targets
TS TS DHFR DHFR GARFT
1.3 nM1.3 nM(Ki)7.2 nM7.2 nM(Ki)65 nM(Ki)
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 9.68 mL 48.41 mL 96.82 mL
0.5 mM 1.94 mL 9.68 mL 19.36 mL
1 mM 0.97 mL 4.84 mL 9.68 mL
5 mM 0.19 mL 0.97 mL 1.94 mL

*The above data is based on the productmolecular weight 1032.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15207
CAS No. 357166-30-4
Formula C40H48N10Na4O17
M. Wt 1032.8
Purity >98%
Synonyms Pemetrexed sodium hydrate (1:2:2.5)
SMILES C1=CC(=CC=C1CCC2=CNC3=C2C(=O)N=C(N3)N)C(=O)NC(CCC(=O)[O-])C(=O)[O-].C1=CC(=CC=C1CCC2=CNC3=C2C(=O)N=C(N3)N)C(=O)NC(CCC(=O)[O-])C(=O)[O-].O.O.O.O.O.[Na+].[Na+].[Na+].[Na+]
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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