Reversine

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Aurora B inhibitor

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Catalog No. A13250

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Reversine 5mg A13250-5

Regular Price: $60.00

Special Price: $51.00

Reversine 10mg A13250-10

Regular Price: $90.00

Special Price: $76.50

Reversine 25mg A13250-25

Regular Price: $180.00

Special Price: $153.00

Reversine 50mg A13250-50

Regular Price: $250.00

Special Price: $212.50

Reversine 10mM * 1mL in DMSO A13250-10mM-D

Regular Price: $75.00

Special Price: $63.75

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Reversine, which induces the dedifferentiation and regeneration of human cells, inhibits MPS1 and Aurora B with IC50 of 6 nM and 98.5 nM, respectively.

Reversine

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Chemical Information

Catalog Num A13250
Actions Inhibitor
M. Wt 393.5
Formula C21H27N7O
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 656820-32-5
Synonyms 0
SMILES code C1CCC(CC1)NC2=NC(=NC3=C2NC=N3)NC4=CC=C(C=C4)N5CCOCC5
Chemical Name N6-?cyclohexyl-?N2-?[4-?(4-?morpholinyl)phenyl]-?1H-?purine-?2,?6-?diamine

Biological Activity

Description
Reversine, which induces the dedifferentiation and regeneration of human cells, inhibits MPS1 and Aurora B with IC50 of 6 nM and 98.5 nM, respectively.
Targets
Aurora A Aurora B Aurora C human A3 adenosine receptor
12 nM13 nM20 nM0.66 μM(Ki)

Solubility

Solubility (25°C)* In vitro DMSO 82 mg/mL heating (208.52 mM)
Water <1 mg/mL (<1 mM)
Ethanol 1 mg/mL heating (2.54 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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