Adezmapimod (SB-203580)

Name: Adezmapimod (SB-203580)
Brand: Adooq Bioscience
SKU: A10824
Rating: 5 (13 reviews)

Catalog No.: A10824

p38 MAPK inhibitor

Adooq's Adezmapimod (SB-203580) has been cited by 13 publications

SB 203580 is a specific inhibitor of p38α and p38β which suppresses downstream activation of MAPKAP kinase-2 and heat shock protein 27.

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Adezmapimod (SB-203580) 152121-47-6 p38 MAPK inhibitor

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Grouped product items
Size	Price	Stock
5mg	$25.00	In stock
10mg	$40.00	In stock
25mg	$45.00	In stock
50mg	$55.00	In stock
100mg	$95.00	In stock
200mg	$165.00	In stock
500mg	$285.00	In stock
*10mM 1mL in DMSO**	$45.00	In stock
Bulk Size	Bulk Discount

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Data Sheet SDS

Other Forms of Adezmapimod (SB-203580)

SB 203580 hydrochloride (Adezmapimod hydrochloride)

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Adooq Products cited in reputable paper

Adooq's Adezmapimod (SB-203580) has been cited by 13 publications

Mustafa Usta, .et al. , J Trace Elem Med Biol, 2025, Aug:90:127694 PMID: 40664043
Jung Hyun Kang, .et al. , Food Sci Biotechnol, 2024, 33: 3629-3637
Masayuki Harada, .et al. , Cell Cycle, 2024, Feb;23(3):308-327 PMID: 38461418
Dan Mao, .et al. , J Oral Biosci, 2024, Mar;66(1):105-111 PMID: 38182046
Lei Zhang, .et al. , Stem Cell Reports, 2022, Jun 14;17(6):1428-1441 PMID: 35561683
Tomoyuki Hashimoto, .et al. , Ann Nucl Med, 2021, Aug 19 PMID: 34410619
Y Zou, .et al. , BMC Cancer, 2019, Oct 15;19(1):949 PMID: 31615459
Wei P, .et al. , Cell Death Dis, 2019, Sep 11;10(9):670 PMID: 31511493
Uwada J, .et al. , Cell Signal, 2019, Nov;63:109358 PMID: 31295519
Byungki Jang, .et al. , Int J Mol Sci, 2017, Nov; 18(11): 2258 PMID: 29077055
Uwada J, .et al. , Cell Signal, 2017, Jul;35:188-196 PMID: 28412413
ZHIQIANG ZHANG, .et al. , Mol Med Rep. , 2015, Jul;12(1):1499-505. PMID: 25815691
Choe YJ, .et al. , Int J Oncol., 2014, 44(3):761-8. PMID: 24366007

Biological Activity

Description

SB 203580 is a specific inhibitor of p38α and p38β which suppresses downstream activation of MAPKAP kinase-2 and heat shock protein 27.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

Product Information

Catalog Num	A10824
Formula	C21H16FN3OS
Molecular Weight	377.4
CAS Number	152121-47-6
SMILES	CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F
Synonyms	SB-203580, SB203580
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility

In vitro (25°C)	DMSO	40 mg/mL (105.97 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+30% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.5 mL	132.49 mL	264.97 mL
0.5 mM	5.3 mL	26.5 mL	52.99 mL
1 mM	2.65 mL	13.25 mL	26.5 mL
5 mM	0.53 mL	2.65 mL	5.3 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂