SB 203580

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p38 MAPK inhibitor

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Catalog No. A10824

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
SB 203580 25mg A10824-25

Regular Price: $50.00

Special Price: $42.50

SB 203580 50mg A10824-50

Regular Price: $80.00

Special Price: $68.00

SB 203580 100mg A10824-100

Regular Price: $120.00

Special Price: $102.00

SB 203580 200mg A10824-200

Regular Price: $230.00

Special Price: $195.50

SB 203580 10mM * 1mL in DMSO A10824-10mM-D

Regular Price: $67.00

Special Price: $56.95

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

SB 203580 is a specific inhibitor of p38α and p38β which suppresses downstream activation of MAPKAP kinase-2 and heat shock protein 27.

SB 203580

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Chemical Information

Catalog Num A10824
Actions Inhibitor
M. Wt 377.4
Formula C21H16FN3OS
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 152121-47-6
Synonyms SB-203580, SB203580
SMILES code CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F
Chemical Name 4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine

Biological Activity

Description
SB 203580 is a specific inhibitor of p38α and p38β which suppresses downstream activation of MAPKAP kinase-2 and heat shock protein 27.
Targets
p38 MAPK (THP-1 cells) PKB (THP-1 cells)
0.3 μM-0.5 μM3 μM-5 μM

Solubility

Solubility (25°C)* In vitro DMSO 43 mg/mL (113.92 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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