SGI-1776 (free base) ON SALE PIM Inhibitor

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Catalog No. A10838

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
SGI-1776 5mg A10838-5

Regular Price: $85.00

Special Price: $72.25

SGI-1776 10mg A10838-10

Regular Price: $150.00

Special Price: $127.50

SGI-1776 25mg A10838-25

Regular Price: $280.00

Special Price: $238.00

SGI-1776 50mg A10838-50

Regular Price: $410.00

Special Price: $348.50

SGI-1776 (free base) 10mM * 1mL in DMSO A10838-10mM-D

Regular Price: $128.00

Special Price: $108.80

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

SGI-1776 is a potent and selective inhibitor of Pim kinases that induces apoptosis in CLL and that the mechanism involves Mcl-1 reduction.

SGI-1776 (free base)

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Chemical Information

Catalog Num A10838
Actions Inhibitor
M. Wt 405.4
Formula C20H22F3N5O
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1025065-69-3
Synonyms SGI1776
SMILES code CN1CCC(CC1)CNC2=NN3C(=NC=C3C4=CC(=CC=C4)OC(F)(F)F)C=C2
Chemical Name N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine sulfate

Biological Activity

Description
SGI-1776 is a potent and selective inhibitor of Pim kinases that induces apoptosis in CLL and that the mechanism involves Mcl-1 reduction.

Solubility

Solubility (25°C) * In vitro DMSO 81 mg/mL (199.79 mM)
Water <1 mg/mL (<1 mM)
Ethanol 81 mg/mL (199.79 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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