Pim

Cat. No.

A13203

CAS No.

1204144-28-4

AZD1208

AZD1208 is orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity.

Cat. No.

A14420

CAS No.

1469925-36-7

LGB-321 HCl

Synonyms: LGB-321

LGB-321 HCl is a potent and selective ATP-competitive small molecule inhibitor of PIM kinases (Pan-PIM kinase inhibitor).

Cat. No.

A10838

CAS No.

1025065-69-3

SGI-1776 (free base)

Synonyms: SGI1776

SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. Phase 1.

Cat. No.

A11945

CAS No.

327033-36-3

(Z)-SMI-4a

Synonyms: SMI4a

SIM-4a is a Pim kinase inhibitor that blocks mTORC1 activity via activation of AMPK. Mostly potent to Pim-2, does not significantly inhibit any other serine/threonine- or tyrosine-kinases.

Cat. No.

A11476

CAS No.

1093222-27-5

Pim1/AAK1-IN-1

Synonyms: LKB1/AAK1 dual inhibitor

Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK.

Cat. No.

A11967

CAS No.

438190-29-5

TCS PIM-1 4a (SMI-4a)

Synonyms: SMI-4a

TCS PIM-1 4a is a selective and ATP-competitive Pim kinase inhibitor (IC50 values = 24 and 100 nM for Pim-1 and Pim-2, respectively).

Cat. No.

A12896

CAS No.

1202916-90-2

CX-6258

CX-6258 is a potent, selective, and orally efficacious pan-Pim kinases inhibitor.

Cat. No.

A13945

CAS No.

1447-88-7

Hispidulin

Synonyms: Dinatin

Hispidulin is a natural flavone with a broad spectrum of biological activities. Hispidulin is a Pim-1 inhibitor with an IC50 of 2.71 μM.

Cat. No.

A14275

CAS No.

1353859-00-3

CX-6258 HCl

Synonyms: CX6258

CX-6258 HCl is a potent, orally efficacious pan-Pim kinase inhibitor with IC50 of 5 nM, 25 nM and 16 nM for Pim1, Pim2, and Pim3.

Cat. No.

A15055

CAS No.

1353858-99-7

CX-6258 hydrochloride hydrate

CX-6258 hydrochloride hydrate is a potent, orally efficacious Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor with excellent biochemical potency and kinase selectivity.

Cat. No.

A15368

CAS No.

477845-12-8

PIM-1 Inhibitor 2

PIM-1 inhibitor 2 is a potent Pim-1 kinase inhibitor (Ki = 91 nM).

Cat. No.

A15369

CAS No.

491871-58-0

TCS PIM-1 1

Synonyms: SC 204330

TCS PIM-1 1 is a potent and selective ATP-competitive Pim-1 kianse inhibitor with IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2(IC50s >20,000 nM).

Cat. No.

A16807

CAS No.

1210608-43-7

PIM447 (LGH447)

Synonyms: LGH-447; LGH447 free base

PIM447 is a novel pan-PIM kinase inhibitor with Ki values of 6 pM, 18 pM, 9 pM for PIM1, PIM2, PIM3 respectively. It also inhibits GSK3β, PKN1, and PKCτ, but at a significantly lower potency with IC50 between 1 and 5 μM (>105-fold differential relative to the Ki on PIMs).

Cat. No.

A16927

CAS No.

1621866-96-3

AZD1208 HCl

Synonyms: AZD 1208

AZD1208 hydrochloride is a novel, orally bioavailable, highly selective PIM kinases inhibitor.

Cat. No.

A17157

CAS No.

587852-28-6

SMI-16a

SMI-16a is a selective Pim kinase inhibitor with IC50 values of 0.15, 0.02 and 48 μM for Pim1, Pim2 and PC3 cells, respectively.

Cat. No.

A19243

CAS No.

1527523-39-2

GNE-955

GNE-955 is a potent and orally active pan Pim kinase inhibitor with Kis of 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively.

Cat. No.

A19392

CAS No.

1417630-95-5

PIM1-IN-1

PIM1-IN-1 is a potent and highly selective PIM1/3 inhibitor, with IC50s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively, inhibits the phosphorylation of BAD, a downstream target of PIM, with an EC50 of 262 nM.

Cat. No.

A20584

CAS No.

1361951-15-6

TP-3654

TP-3654 is a second-generation Pim kinase inhibitor with Ki values of 5 and 42 nM for Pim-1 and Pim-3, respectively.

Cat. No.

A20920

CAS No.

1428569-85-0

GDC-0339

GDC-0339 is a potent, orally bioavailable and well tolerated pan-Pim kinase inhibitor, with Kis of 0.03 nM, 0.1 nM and 0.02 nM for Pim1, Pim2 and Pim3, respectively. GDC-0339 is discovered as a potential treatment of multiple myeloma.

Cat. No.

A21444

CAS No.

2088852-47-3

INCB053914 phosphate

Synonyms: INCB 053914

INCB053914 phosphate is an inhibitor of Pim extracted from patent WO 2017044730 A1, compound 1; has an IC50 of less than 35 nM.

Cat. No.

A22203

CAS No.

1616359-00-2

SEL24-B489

Synonyms: MEN1703; SEL24

SEL24-B489 is a potent, type I, orally active dual inhibitor of PIM kinases and FLT3-ITD. It exhibits high affinity for PIM family members, with Kd values of 2 nM for PIM1, 2 nM for PIM2, and 3 nM for PIM3, making it a promising candidate for targeted cancer therapy.

Cat. No.

A25140

CAS No.

1902983-63-4

JP-11646

JP-11646 is a potent pan-PIM inhibitor specifically targeting PIM2 with an IC50 of 0.5 nM. This reversible, ATP non-competitive inhibitor significantly reduces the mRNA levels of PIM1, PIM2, and PIM3. JP-11646 has demonstrated efficacy in inhibiting cell viability in small cell lung cancer (SCLC) and large cell neuroendocrine carcinomas of the lung (LCNEC), leading to apoptosis or necroptosis through decreased p-4EBP-1 and altered caspase activity. This reagent is valuable for research applications in SCLC, LCNEC, acute myeloid leukemia (AML), multiple myeloma (MM), and triple-negative breast cancer (TNBC).

Cat. No.

A25155

CAS No.

2918764-57-3

Pim-1 kinase inhibitor 10

Pim-1 kinase inhibitor 10 is a selective inhibitor of PIM-1 and PIM-2 kinases, functioning through both competitive and non-competitive mechanisms. This compound effectively induces apoptosis in cancer cells, demonstrating significant anticancer activity. Additionally, Pim-1 kinase inhibitor 10 activates caspase 3 and 7, further contributing to its potential as a therapeutic agent in cancer research.

Cat. No.

A25844

CAS No.

1414455-21-2

IBL-302

Synonyms: AMU302

IBL-302 is an orally available dual inhibitor targeting PIM and the PI3K/AKT/mTOR pathways. It exhibits significant antitumor activity against breast cancer and neuroblastoma, showing in vivo efficacy in nude mouse xenograft models by overcoming trastuzumab resistance. Additionally, IBL-302 enhances the cytotoxic effects of commonly used chemotherapeutic agents, including cisplatin, doxorubicin, and etoposide, making it a valuable compound for cancer research applications.

Cat. No.

A30245

CAS No.

956123-34-5

CRT0066101

CRT0066101 is a potent and orally active inhibitor of Protein Kinase D (PKD) with IC50 values of 1 nM, 2.5 nM, and 2 nM for PKD1, PKD2, and PKD3, respectively. Additionally, it serves as an effective PIM2 inhibitor with an IC50 of approximately 135.7 nM. This compound exhibits notable anti-inflammatory activity demonstrated in LPS-induced lung injury models in mice, as well as anticancer effects, making it a valuable tool for research in cancer and inflammation-related studies.