Sunitinib Malate

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Catalog No. A10880

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Sunitinib Malate 50mg A10880-50

Regular Price: $40.00

Special Price: $34.00

Sunitinib Malate 100mg A10880-100

Regular Price: $65.00

Special Price: $55.25

Sunitinib Malate 200mg A10880-200

Regular Price: $100.00

Special Price: $85.00

Sunitinib Malate 500mg A10880-500

Regular Price: $200.00

Special Price: $170.00

Sunitinib Malate 10mM * 1mL in DMSO A10880-10mM-D

Regular Price: $63.00

Special Price: $53.55

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Sunitinib is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST).

Sunitinib Malate

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Chemical Information

Catalog Num A10880
Actions N/A
M. Wt 532.6
Formula C22H27FN4O2.C4H6O5
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 341031-54-7
Synonyms SU-11248
SMILES code CCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C\2/C3=C(C=CC(=C3)F)NC2=O)C.C([C@@H](C(=O)O)O)C(=O)O
Chemical Name N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybutanedioate

Biological Activity

Description
Sunitinib is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST).
Targets
Target Value
Kit
FLT3
PDGFRβIC50: 2nM
VEGFR2IC50: 80nM
FGFR1IC50: 2.9μM
EGFRIC50: >20μM

Solubility

Solubility (25°C) * In vitro DMSO 15 mg/mL (28.16 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% CMC, pH3.5 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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