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N-desethyl sunitinib is a major and pharmacologically active metabolite of sunitinib, which is potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor (Ki values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT respectively).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27 mL | 134.98 mL | 269.96 mL |
| 0.5 mM | 5.4 mL | 27 mL | 53.99 mL |
| 1 mM | 2.7 mL | 13.5 mL | 27 mL |
| 5 mM | 0.54 mL | 2.7 mL | 5.4 mL |
*The above data is based on the productmolecular weight 370.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15182 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 356068-97-8 |
| Formula | C20H23FN4O2 |
| M. Wt | 370.42 |
| Purity | >98% |
| Synonyms | SU11662, SU 11662, SU-11662 |
| SMILES | CCNCCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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