N-Desethyl Sunitinib

Catalog No.: A15182

VEGFR/PDGFRβ/KIT inhibitor

N-Desethyl Sunitinib

N-Desethyl Sunitinib Chemical Structure

CAS NO. 356068-97-8

N-desethyl sunitinib is a major and pharmacologically active metabolite of sunitinib, which is potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor (Ki values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT respectively).

Availability: In stock

Package Price Qty
5 mg
$225.00
10 mg
$315.00
50 mg
$785.00
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Biological Activity

N-desethyl sunitinib is a major and pharmacologically active metabolite of sunitinib, which is potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor (Ki values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT respectively).
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27 mL 134.98 mL 269.96 mL
0.5 mM 5.4 mL 27 mL 53.99 mL
1 mM 2.7 mL 13.5 mL 27 mL
5 mM 0.54 mL 2.7 mL 5.4 mL

*The above data is based on the productmolecular weight 370.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15182
Actions Inhibitor
CAS No. 356068-97-8
Formula C20H23FN4O2
M. Wt 370.42
Purity >98%
Synonyms SU11662, SU 11662, SU-11662
SMILES CCNCCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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