U0126-EtOH

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MEK inhibitor

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Catalog No. A10957

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
U0126-EtOH 25mg A10957-25
$60.00
U0126-EtOH 50mg A10957-50
$80.00
U0126-EtOH 100mg A10957-100
$110.00
U0126-EtOH 250mg A10957-250
$180.00
U0126-EtOH 10mM * 1mL in DMSO A10957-10mM-D
$50.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

U0126-EtOH is an inhibitor of both MEK1 and MEK2 with an IC50 of 72 nM and 58 nM respectively.

U0126-EtOH

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Chemical Information

Catalog Num A10957
Actions Inhibitor
M. Wt 426.6
Formula C18H16N6S2.C2H6O
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1173097-76-1
Synonyms N/A
SMILES code CCO.C1=CC=C(C(=C1)N)S/C(=C(/C(=C(/SC2=CC=CC=C2N)\N)/C#N)\C#N)/N
Chemical Name (2Z,3Z)-2,3-bis[amino-(2-aminophenyl)sulfanylmethylidene]butanedinitrile; ethanol

Biological Activity

Description
U0126-EtOH is an inhibitor of both MEK1 and MEK2 with an IC50 of 72 nM and 58 nM respectively.
Targets
Target Value
MEK2IC50: 0.06μM
MEK1IC50: 0.07μM
PKCIC50: >10μM
CDK2IC50: >10μM
CDK4IC50: >10μM
MKK6/p38MAPKIC50: 20μM
MKK3/p38MAPKIC50: 38μM
ERK1/2IC50: >50μM
JNKIC50: >100μM
MKK4IC50: >100μM
AblIC50: >100μM

Solubility

Solubility (25°C) * In vitro DMSO 85 mg/mL (199.26 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 2% Cremophor EL, 2% N,N-dimethylacetamide 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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